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健康与疾病的发育起源框架与进化人类学多个分支之间的协同作用。

Synergies between the Developmental Origins of Health and Disease framework and multiple branches of evolutionary anthropology.

机构信息

Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.

Department of Anthropology, McMaster University, Hamilton, Ontario, Canada.

出版信息

Evol Anthropol. 2020 Sep;29(5):214-219. doi: 10.1002/evan.21860. Epub 2020 Sep 2.

Abstract

The Developmental Origins of Health and Disease (DOHaD) hypothesis derives from the epidemiological and basic/mechanistic health sciences. This well-supported hypothesis holds that environment during the earliest stages of life-pre-conception, pregnancy, infancy-shapes developmental trajectories and ultimately health outcomes across the lifespan. Evolutionary anthropologists from multiple subdisciplines are embracing synergies between the DOHaD framework and developmentalist approaches from evolutionary biology. Even wider dissemination and employment of DOHaD concepts will benefit evolutionary anthropological research. Insights from experimental DOHaD work will focus anthropologists' attention on biochemical/physiological mechanisms underpinning observed links between growth/health/behavioral outcomes and environmental contexts. Furthermore, the communication tools and wide public appeal of developmentalist health scientific research may facilitate the translation/application of evolutionary anthropological findings. Evolutionary Anthropology, in turn, can increase mainstream DOHaD research's use of evolutionary theory; holistic, longitudinal, and community-based perspectives; and engagement with populations whose environmental exposures differ from those most commonly studied in the health sciences.

摘要

健康与疾病的发育起源(DOHaD)假说源自流行病学和基础/机制健康科学。这一得到充分支持的假说认为,生命早期(受孕前、怀孕期和婴儿期)的环境会影响发育轨迹,并最终影响整个生命周期的健康结果。来自多个子学科的进化人类学家正在接受 DOHaD 框架与进化生物学中发展主义方法之间的协同作用。更广泛地传播和运用 DOHaD 概念将有益于进化人类学研究。实验 DOHaD 工作的见解将使人类学家关注支持观察到的生长/健康/行为结果与环境背景之间联系的生化/生理机制。此外,发展主义健康科学研究的交流工具和广泛的公众吸引力可能有助于将进化人类学发现转化为应用。反过来,进化人类学可以增加主流 DOHaD 研究对进化理论的使用;整体、纵向和基于社区的观点;以及与那些环境暴露与健康科学中最常研究的环境暴露不同的人群的接触。

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