新型棘白菌素衍生物LY121019的抗真菌活性研究
A study of the antifungal activity of LY121019, a new echinocandin derivative.
作者信息
Strippoli V, D'Auria F D, Simonetti N
机构信息
Institute of Microbiology, University of Rome, Italy.
出版信息
Chemioterapia. 1988 Feb;7(1):33-7.
LY121019 is a cyclic peptide antibiotic of the echinocandin group, which is characterized by strong anti-Candida activity (in particular against Candida albicans) as well as by low experimental toxicity. Its anti-Candida activity is thought to be due to an inhibition of the synthesis of beta-glucan, an essential cell wall polysaccharide. The different composition of culture media or the presence of animal serum did not show adverse effects on LY121019's anti-Candida activity and the addition of reducing compounds such as cysteine and hydroquinone did not manifest a negative influence. Analogously the anti-Candida activity was not influenced when C. albicans was grown under aeration. The activity of LY121019 was very high against the mycelial form of C. albicans even when this form was developed in the presence of animal serum.
LY121019是棘白菌素类的环肽抗生素，其特点是具有强大的抗念珠菌活性（特别是针对白色念珠菌）以及低实验毒性。其抗念珠菌活性被认为是由于抑制了β-葡聚糖（一种重要的细胞壁多糖）的合成。不同的培养基组成或动物血清的存在对LY121019的抗念珠菌活性没有显示出不利影响，并且添加半胱氨酸和对苯二酚等还原化合物也没有表现出负面影响。类似地，当白色念珠菌在通气条件下生长时，其抗念珠菌活性也不受影响。即使白色念珠菌的菌丝体形式是在动物血清存在的情况下形成的，LY121019对其活性也非常高。
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