循环代谢物与脑萎缩和脑白质高信号有关。
Circulating metabolites are associated with brain atrophy and white matter hyperintensities.
机构信息
Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.
Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
出版信息
Alzheimers Dement. 2021 Feb;17(2):205-214. doi: 10.1002/alz.12180. Epub 2020 Sep 4.
INTRODUCTION
Our aim was to study whether systemic metabolites are associated with magnetic resonance imaging (MRI) measures of brain and hippocampal atrophy and white matter hyperintensities (WMH).
METHODS
We studied associations of 143 plasma-based metabolites with MRI measures of brain and hippocampal atrophy and WMH in three independent cohorts (n = 3962). We meta-analyzed the results of linear regression analyses to determine the association of metabolites with MRI measures.
RESULTS
Higher glucose levels and lower levels of three small high density lipoprotein (HDL) particles were associated with brain atrophy. Higher glucose levels were associated with WMH.
DISCUSSION
Glucose levels were associated with brain atrophy and WMH, and small HDL particle levels were associated with brain atrophy. Circulating metabolites may aid in developing future intervention trials.
简介
我们旨在研究系统代谢物是否与脑和海马体萎缩以及脑白质高信号（WMH）的磁共振成像（MRI）测量结果相关。
方法
我们研究了 143 种基于血浆的代谢物与三个独立队列（n=3962）的脑和海马体萎缩以及 WMH 的 MRI 测量值之间的关联。我们对线性回归分析的结果进行了荟萃分析，以确定代谢物与 MRI 测量值之间的关联。
结果
较高的葡萄糖水平和较低的三种小高密度脂蛋白（HDL）颗粒水平与脑萎缩有关。较高的葡萄糖水平与 WMH 有关。
讨论
葡萄糖水平与脑萎缩和 WMH 有关，而小 HDL 颗粒水平与脑萎缩有关。循环代谢物可能有助于未来干预试验的发展。
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