Department of Virology, Medicum, University of Helsinki, Helsinki, Finland.
Department of Veterinary Biosciences, University of Helsinki, Helsinki, Finland.
Vector Borne Zoonotic Dis. 2020 Nov;20(11):843-849. doi: 10.1089/vbz.2019.2562. Epub 2020 Sep 7.
Sindbis virus (SINV) is a mosquito-borne avian hosted virus that is widely distributed in Europe, Africa, Asia, and Oceania. Disease in humans is documented mainly from Northern Europe and South Africa and associated with genotype I. In 2018 under extremely warm climatic conditions, a small outbreak of 71 diagnosed SINV infections was recorded in Finland. We screened 52 mosquito pools (570 mosquitoes) and 223 human sera for SINV with real-time RT-PCR and the positive samples with virus isolation. One SINV strain was isolated from a pool ( = 13) of genus mosquitoes and three strains from patient serum samples. Complete genome analysis suggested all the isolates to be divergent from one another and related to previous Finnish, Swedish, and German strains. The study provides evidence of SINV strain transfer within Europe across regions with different epidemiological characteristics. Whether these are influenced by different mosquito genera involved in the transmission remains to be studied.
辛德毕斯病毒（SINV）是一种经蚊子传播的禽源性病毒，广泛分布于欧洲、非洲、亚洲和大洋洲。人类疾病主要记录于北欧和南非，与基因型 I 有关。2018 年，在极其温暖的气候条件下，芬兰记录了一起 71 例确诊的辛德毕斯病毒感染的小型暴发。我们使用实时 RT-PCR 对 52 个蚊子池（570 只蚊子）和 223 份人类血清进行了 SINV 筛查，并对阳性样本进行了病毒分离。从一个（ = 13）属蚊子的蚊子池中分离到 1 株 SINV 株，从 3 例患者血清样本中分离到 3 株。全基因组分析表明，所有分离株彼此之间存在差异，与之前的芬兰、瑞典和德国株有关。该研究提供了证据表明，SINV 株在具有不同流行病学特征的欧洲区域内传播。是否存在不同的传播蚊子属参与其中，仍有待研究。
