Dermatest GmbH, Engelstrasse, Münster, Germany.
Amsterdam UMC, Location AMC, Coronel Institute, Meibergdreef, AZ Amsterdam, The Netherlands.
Ann Work Expo Health. 2021 Mar 3;65(2):201-205. doi: 10.1093/annweh/wxaa085.
Irritant contact dermatitis is a wide spread occupational skin condition. In addition to generalized protection and teaching schemes, a knowledge about individual risk might add to an improved awareness for hazards. Here, we report on a novel candidate biomarker, which might stage individual susceptibility to irritant skin damage. Subclinical sensitivity was proven in recent studies. As a nano-anatomical measure, it works non-invasively on corneocytes from tape strips. Here, we report on a 7-day course after exposure to sodium lauryl sulphate and compare the novel cell texture index with the classical markers water loss (transepidermal water loss) and natural moisturizing factor. All parameters show a high degree of correlation.
刺激性接触性皮炎是一种广泛存在的职业性皮肤疾病。除了一般的防护和教育方案外，对个体风险的了解可能有助于提高对危害的认识。在这里，我们报告了一种新的候选生物标志物，它可能可以预测个体对刺激性皮肤损伤的易感性。在最近的研究中已经证明了亚临床敏感性。作为一种纳米解剖学测量方法，它可以非侵入性地作用于胶带条上的角质形成细胞。在这里，我们报告了接触月桂基硫酸钠后 7 天的过程，并将新型细胞纹理指数与经典标志物水分流失（经表皮水分流失）和天然保湿因子进行了比较。所有参数都显示出高度的相关性。
