Oregon Health & Science University, Portland, Oregon, USA.
Kaiser Permanente Center for Health Research, Portland, Oregon, USA.
Obesity (Silver Spring). 2020 Nov;28(11):2209-2215. doi: 10.1002/oby.22944. Epub 2020 Sep 11.
This study aimed to examine whether pregnancy following bariatric surgery affects long-term maternal weight change and offspring birth weight.
Using data from the Longitudinal Assessment of Bariatric Surgery (LABS)-2 study, linear regression was used to evaluate percent change in total body weight over a 5-year follow-up period among reproductive-aged women who underwent Roux-en-Y gastric bypass or laparoscopic adjustable gastric banding as well as evaluate the association of bariatric procedure type and offspring birth weight.
Of 727 women with preoperative age of 36.1 (6.3) years (mean [SD]) and BMI of 46.9 (7.0) kg/m , 80 (11%) reported at least one pregnancy. After adjusting for covariates, percent change in total body weight was not significantly different between women who became pregnant and those who did not during a 5-year follow-up period (β = 2.02; 95% CI: -1.03 to 5.07; P = 0.19). Additionally, mean birth weight was not significantly different between mothers who underwent Roux-en-Y gastric bypass versus laparoscopic adjustable gastric banding (P = 0.99).
Postoperative pregnancy did not diminish long-term weight loss in women in the LABS-2 study. The finding of comparable weight loss is relevant for providers counseling women of reproductive age on weight-loss expectations and family planning following bariatric surgery.
本研究旨在探讨减重手术后妊娠是否会影响产妇体重的长期变化和后代出生体重。
本研究利用纵向评估减重手术（LABS-2 研究）的数据，采用线性回归评估了接受 Roux-en-Y 胃旁路术或腹腔镜可调节胃束带术的育龄妇女在 5 年随访期间总体重变化的百分比，以及评估了减重手术类型与后代出生体重的关系。
在 727 名术前年龄为 36.1（6.3）岁（均值[标准差]）和 BMI 为 46.9（7.0）kg/m²的女性中，有 80 名（11%）报告至少有一次妊娠。在调整了协变量后，在 5 年随访期间，怀孕的女性与未怀孕的女性之间的总体重变化百分比没有显著差异（β=2.02；95%CI：-1.03 至 5.07；P=0.19）。此外，接受 Roux-en-Y 胃旁路术与腹腔镜可调节胃束带术的母亲的后代出生体重没有显著差异（P=0.99）。
在 LABS-2 研究中，术后妊娠并没有减少女性的长期体重减轻。这一发现对于为接受减重手术的育龄妇女提供有关减重期望和计划生育的咨询的提供者具有重要意义。
