胃饥饿素与血管保护
Ghrelin and vascular protection.
作者信息
Pearson James T, Shirai Mikiyasu, Sukumaran Vijayakumar, Du Cheng-Kun, Tsuchimochi Hirotsugu, Sonobe Takashi, Waddingham Mark T, Katare Rajesh, Schwenke Daryl O
机构信息
Department of Cardiac Physiology, National Cerebral and Cardiovascular Center Research Institute, Osaka, Japan.
Department of Physiology and Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
出版信息
Vasc Biol. 2019 Sep 5;1(1):H97-H102. doi: 10.1530/VB-19-0024. eCollection 2019.
Ghrelin is a small peptide with important roles in the regulation of appetite, gut motility, glucose homeostasis as well as cardiovascular protection. This review highlights the role that acyl ghrelin plays in maintaining normal endothelial function by maintaining the balance of vasodilator-vasoconstrictor factors, inhibiting inflammatory cytokine production and immune cell recruitment to sites of vascular injury and by promoting angiogenesis.
胃饥饿素是一种小肽，在食欲调节、肠道蠕动、葡萄糖稳态以及心血管保护方面发挥着重要作用。本综述强调了酰基化胃饥饿素通过维持血管舒张因子与血管收缩因子的平衡、抑制炎性细胞因子的产生以及免疫细胞向血管损伤部位的募集，并促进血管生成，从而在维持正常内皮功能中所起的作用。
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