Ghadiri Amir Mohammad, Rabiee Navid, Bagherzadeh Mojtaba, Kiani Mahsa, Fatahi Yousef, Di Bartolomeo Antonio, Dinarvand Rassoul, Webster Thomas J
Department of Chemistry, Sharif University of Technology, Tehran, Iran.
Nanotechnology. 2020 Jun 30;31(42):425101. doi: 10.1088/1361-6528/aba142.
This study, for the first time, reports the synthesis of CuO- and CuO nanoparticles (NPs) using the Salvia hispanica extract by a high-gravity technique. The original green synthesis procedure led to the formation of nanoparticles with promising catalytic and biological properties. The synthesized nanoparticles were fully characterized and their catalytic activity was evaluated through a typical Azide-Alkyne Cycloaddition (AAC) reaction. The potential antibacterial activity against gram positive (S. aureus) and gram negative (E. coli) bacteria were investigated. It was shown that the antibacterial properties were independent of the NP morphology as well as of the texture of the synthesis media. As a result, the presently synthesized nanoparticles showed very good photocatalytic and catalytic activities in comparison with the literature. From a biological perspective, they showed lower cytotoxicity in comparison with the literature, and also showed higher antioxidant and antibacterial activities. Thus, these present green CuO and CuO nanoparticles deserve further attention to improve numerous medical applications.
本研究首次报道了采用高重力技术，利用鼠尾草提取物合成氧化铜和氧化铜纳米颗粒（NPs）。原始的绿色合成方法导致形成了具有良好催化和生物学特性的纳米颗粒。对合成的纳米颗粒进行了全面表征，并通过典型的叠氮化物-炔烃环加成（AAC）反应评估了它们的催化活性。研究了其对革兰氏阳性菌（金黄色葡萄球菌）和革兰氏阴性菌（大肠杆菌）的潜在抗菌活性。结果表明，抗菌性能与纳米颗粒形态以及合成介质的质地无关。因此，与文献相比，目前合成的纳米颗粒表现出非常好的光催化和催化活性。从生物学角度来看，与文献相比，它们表现出较低的细胞毒性，并且还表现出较高的抗氧化和抗菌活性。因此，这些绿色的氧化铜和氧化铜纳米颗粒值得进一步关注，以改善众多医学应用。
