Naomi Ruth, Ardhani Retno, Hafiyyah Osa Amila, Fauzi Mh Busra
Centre for Tissue Engineering and Regenerative Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, Cheras, Kuala Lumpur 56000, Malaysia.
Department of Dental Biomedical Sciences, Faculty of Dentistry, Universitas Gadjah Mada, Jl Denta Sekip Utara, Yogyakarta 55281, Indonesia.
Polymers (Basel). 2020 Sep 13;12(9):2081. doi: 10.3390/polym12092081.
Collagen (Col) is a naturally available material and is widely used in the tissue engineering and medical field owing to its high biocompatibility and malleability. Promising results on the use of Col were observed in the periodontal application and many attempts have been carried out to inculcate Col for gingival recession (GR). Col is found to be an excellent provisional bioscaffold for the current treatment in GR. Therefore, the aim of this paper is to scrutinize an overview of the reported Col effect focusing on in vitro, in vivo, and clinical trials in GR application. A comprehensive literature search was performed using EBSCOhost, Science Direct, Springer Link, and Medline & Ovid databases to identify the potential articles on particular topics. The search query was accomplished based on the Boolean operators involving keywords such as (1) collagen OR scaffold OR hybrid scaffold OR biomaterial AND (2) gingiva recession OR tissue regeneration OR dental tissue OR healing mechanism OR gingiva. Only articles published from 2015 onwards were selected for further analysis. This review includes the physicochemical properties of Col scaffold and the outcome for GR. The comprehensive literature search retrieved a total of 3077 articles using the appropriate keywords. However, on the basis of the inclusion and exclusion criteria, only 15 articles were chosen for further review. The results from these articles indicated that Col promoted gingival tissue regeneration for GR healing. Therefore, this systematic review recapitulated that Col enhances regeneration of gingival tissue either through a slow or rapid process with no sign of cytotoxicity or adverse effect.
胶原蛋白（Col）是一种天然存在的材料，因其具有高生物相容性和可塑性，在组织工程和医学领域得到广泛应用。在牙周应用中，使用Col取得了令人满意的结果，并且已经进行了许多尝试将Col应用于牙龈退缩（GR）。Col被发现是目前GR治疗中一种出色的临时生物支架。因此，本文的目的是审视已报道的Col效应的概述，重点关注GR应用中的体外、体内和临床试验。使用EBSCOhost、Science Direct、Springer Link以及Medline & Ovid数据库进行了全面的文献检索，以识别特定主题的潜在文章。搜索查询基于布尔运算符完成，涉及的关键词如（1）胶原蛋白或支架或混合支架或生物材料以及（2）牙龈退缩或组织再生或牙齿组织或愈合机制或牙龈。仅选择2015年以后发表的文章进行进一步分析。本综述包括Col支架的物理化学性质以及GR的结果。使用适当的关键词进行全面文献检索共检索到3077篇文章。然而，根据纳入和排除标准，仅选择了15篇文章进行进一步综述。这些文章的结果表明，Col促进了GR愈合的牙龈组织再生。因此，本系统综述总结认为，Col通过缓慢或快速过程增强牙龈组织再生，且无细胞毒性或不良反应迹象。
