Naomi Ruth, Ratanavaraporn Juthamas, Fauzi Mh Busra
Centre For Tissue Engineering & Regenerative Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, Cheras, Kuala Lumpur 56000, Malaysia.
Department of Chemical Engineering, Faculty of Engineering, Chulalongkorn University, PhayaThai Road, Pathumwan, Bangkok 10330, Thailand.
Materials (Basel). 2020 Jul 10;13(14):3097. doi: 10.3390/ma13143097.
The use of hybridisation strategy in biomaterials technology provides a powerful synergistic effect as a functional matrix. Silk fibroin (SF) has been widely used for drug delivery, and collagen (Col) resembles the extracellular matrix (ECM). This systematic review was performed to scrutinise the outcome of hybrid Col and SF for cutaneous wound healing. This paper reviewed the progress of related research based on in vitro and in vivo studies and the influence of the physicochemical properties of the hybrid in wound healing. The results indicated the positive outcome of hybridising Col and SF for cutaneous wound healing. The hybridisation of these biomaterials exhibits an excellent moisturising property, perfectly interconnected structure, excellent water absorption and retention capacity, an acceptable range of biodegradability, and synergistic effects in cell viability. The in vitro and in vivo studies clearly showed a promising outcome in the acceleration of cutaneous wound healing using an SF and Col hybrid scaffold. The review of this study can be used to design an appropriate hybrid scaffold for cutaneous wound healing. Therefore, this systematic review recapitulated that the hybridisation of Col and SF promoted rapid cutaneous healing through immediate wound closure and reepithelisation, with no sign of adverse events. This paper concludes on the need for further investigations of the hybrid SF and Col in the future to ensure that the hybrid biomaterials are well-suited for human skin.
在生物材料技术中使用杂交策略可作为一种功能性基质产生强大的协同效应。丝素蛋白（SF）已被广泛用于药物递送，而胶原蛋白（Col）类似于细胞外基质（ECM）。进行这项系统评价以审视Col和SF杂交对皮肤伤口愈合的效果。本文基于体外和体内研究回顾了相关研究进展以及杂交体的物理化学性质对伤口愈合的影响。结果表明Col和SF杂交对皮肤伤口愈合有积极效果。这些生物材料的杂交表现出优异的保湿性能、完美的相互连接结构、出色的吸水和保水能力、可接受的生物降解范围以及对细胞活力的协同效应。体外和体内研究清楚地表明，使用SF和Col杂交支架在加速皮肤伤口愈合方面有良好前景。本研究的综述可用于设计适合皮肤伤口愈合的杂交支架。因此，这项系统评价总结认为，Col和SF杂交通过立即闭合伤口和重新上皮化促进了快速皮肤愈合，且无不良事件迹象。本文得出结论，未来需要对SF和Col杂交体进行进一步研究，以确保杂交生物材料非常适合人类皮肤。
