Department of Environmental Science (ACES), Stockholm University, 106 91 Stockholm, Sweden.
Environ Sci Process Impacts. 2020 Oct 1;22(10):2023-2030. doi: 10.1039/d0em00077a. Epub 2020 Sep 17.
Twenty per- and polyfluoroalkyl substances (PFAS) were determined in human milk from residents of three Chinese cities (Shanghai, Jiaxing, and Shaoxing; [n = 10 individuals per city]), sampled between 2010 and 2016. These data were compared to a combination of new and previously reported PFAS concentrations in human milk from Stockholm, Sweden, collected in 2016 (n = 10 individuals). Across the three Chinese cities, perfluorooctanoate (PFOA; sum isomers), 9-chlorohexadecafluoro-3-oxanone-1-sulfonic acid (9Cl-PF3ONS; also known as 6:2 Cl-PFESA or by its trade name "F53-B"), and perfluorooctane sulfonate (PFOS; sum isomers) occurred at the highest concentrations among all PFAS (up to 411, 976, and 321 pg mL, respectively), while in Stockholm, PFOA and PFOS were dominant (up to 89 and 72 pg mL, respectively). 3H-Perfluoro-3-[(3-methoxy-propoxy)propanoic acid] (ADONA) was intermittently detected but at concentrations below the method quantification limit (i.e. <10 pg mL) in Chinese samples, and was non-detectable in Swedish milk. The extremely high concentrations of F53-B in Chinese milk suggest that human exposure assessments focused only on legacy substances may severely underestimate overall PFAS exposure in breastfeeding infants.
在 2010 年至 2016 年间，采集了来自中国三个城市（上海、嘉兴和绍兴；每个城市 10 个人）的居民的人乳样本，检测了 20 种全氟和多氟烷基物质（PFAS）。将这些数据与 2016 年在瑞典斯德哥尔摩采集的人乳中（10 个人）新的和之前报告过的 PFAS 浓度的组合数据进行了比较。在这三个中国城市中，全氟辛烷酸（PFOA；总异构体）、9-氯十六氟-3-氧杂壬酮-1-磺酸（9Cl-PF3ONS；也称为 6:2 Cl-PFESA 或商品名“F53-B”）和全氟辛烷磺酸（PFOS；总异构体）在所有 PFAS 中的浓度最高（分别高达 411、976 和 321 pg/mL），而在斯德哥尔摩，PFOA 和 PFOS 占主导地位（分别高达 89 和 72 pg/mL）。3H-全氟-3-[(3-甲氧基-丙氧基)丙基]酸（ADONA）间歇性检测到，但在中国人乳中的浓度低于方法定量限（即 <10 pg/mL），在瑞典乳中未检出。中国母乳中 F53-B 的极高浓度表明，仅关注传统物质的人类暴露评估可能严重低估了母乳喂养婴儿的总体 PFAS 暴露。
