体外和体内增强骨细胞功能的材料参数综述。
Review on material parameters to enhance bone cell function in vitro and in vivo.
机构信息
Department of Biologic and Materials Sciences, University of Michigan, Ann Arbor, Michigan, U.S.A.
Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, U.S.A.
出版信息
Biochem Soc Trans. 2020 Oct 30;48(5):2039-2050. doi: 10.1042/BST20200210.
Bone plays critical roles in support, protection, movement, and metabolism. Although bone has an innate capacity for regeneration, this capacity is limited, and many bone injuries and diseases require intervention. Biomaterials are a critical component of many treatments to restore bone function and include non-resorbable implants to augment bone and resorbable materials to guide regeneration. Biomaterials can vary considerably in their biocompatibility and bioactivity, which are functions of specific material parameters. The success of biomaterials in bone augmentation and regeneration is based on their effects on the function of bone cells. Such functions include adhesion, migration, inflammation, proliferation, communication, differentiation, resorption, and vascularization. This review will focus on how different material parameters can enhance bone cell function both in vitro and in vivo.
骨骼在支撑、保护、运动和代谢方面起着至关重要的作用。尽管骨骼具有内在的再生能力，但这种能力是有限的，许多骨骼损伤和疾病需要干预。生物材料是许多恢复骨骼功能的治疗方法的关键组成部分，包括用于增强骨骼的不可吸收植入物和用于引导再生的可吸收材料。生物材料在生物相容性和生物活性方面差异很大，而这些功能取决于特定的材料参数。生物材料在骨增强和再生中的成功基于它们对骨细胞功能的影响。这些功能包括黏附、迁移、炎症、增殖、通讯、分化、吸收和血管生成。本综述将重点介绍不同的材料参数如何在体外和体内增强骨细胞功能。
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