Sarker Avik, Leary Martin, Fox Kate
Centre for Additive Manufacturing, School of Engineering, RMIT University, Melbourne, VIC 3000, Australia.
Biointerphases. 2020 Sep 17;15(5):050801. doi: 10.1116/6.0000414.
This review investigates the available metallic powder bed additive manufacturing technologies with respect to their basic principles and capabilities in terms of developing orthopedic implants. Detailed descriptions of commonly used metallic alloys employed for orthopedic applications are also presented. The relationship between implant surface properties and cellular attachment and the formation of bacterial colonies are also discussed. Accordingly, we show how different surface modification techniques have been applied to improve both the biointerface of metallic implants for enhanced osseointegration and to control the formation of biofilm to protect against implant infection. In addition, the future direction of metallic additive manufacturing in the case of improving bone interface has been discussed. This review aids in the design of bone-interfacing metallic implants fabricated by additive manufacturing processes, specifically accommodating enhanced biointerfaces for the next generation patient-specific orthopedic implants.
本综述研究了现有的金属粉末床增材制造技术，涉及它们在开发骨科植入物方面的基本原理和能力。还介绍了用于骨科应用的常用金属合金的详细描述。此外，还讨论了植入物表面特性与细胞附着以及细菌菌落形成之间的关系。因此，我们展示了如何应用不同的表面改性技术来改善金属植入物的生物界面以增强骨整合，并控制生物膜的形成以防止植入物感染。此外，还讨论了金属增材制造在改善骨界面方面的未来方向。本综述有助于通过增材制造工艺设计与骨界面结合的金属植入物，特别是为下一代定制骨科植入物提供增强的生物界面。
