Department of Electrical and Computer Engineering, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA 90024, USA.
Department of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA 90024, USA.
Neuron. 2020 Oct 28;108(2):322-334.e9. doi: 10.1016/j.neuron.2020.08.021. Epub 2020 Sep 17.
Uncovering the neural mechanisms underlying human natural ambulatory behavior is a major challenge for neuroscience. Current commercially available implantable devices that allow for recording and stimulation of deep brain activity in humans can provide invaluable intrinsic brain signals but are not inherently designed for research and thus lack flexible control and integration with wearable sensors. We developed a mobile deep brain recording and stimulation (Mo-DBRS) platform that enables wireless and programmable intracranial electroencephalographic recording and electrical stimulation integrated and synchronized with virtual reality/augmented reality (VR/AR) and wearables capable of external measurements (e.g., motion capture, heart rate, skin conductance, respiration, eye tracking, and scalp EEG). When used in freely moving humans with implanted neural devices, this platform is adaptable to ecologically valid environments conducive to elucidating the neural mechanisms underlying naturalistic behaviors and to the development of viable therapies for neurologic and psychiatric disorders.
揭示人类自然活动行为的神经机制是神经科学的一大挑战。目前市场上可用于记录和刺激人类大脑深部活动的植入式设备可以提供非常有价值的内在大脑信号，但这些设备并非专门为研究而设计，因此缺乏灵活的控制和与可穿戴传感器的集成。我们开发了一种移动的深部脑记录和刺激（Mo-DBRS）平台，该平台能够实现无线和可编程的颅内脑电图记录和电刺激，与虚拟现实/增强现实（VR/AR）和可穿戴设备集成和同步，这些可穿戴设备能够进行外部测量（例如，运动捕捉、心率、皮肤电导、呼吸、眼动追踪和头皮 EEG）。当在植入神经设备的自由移动的人类中使用时，该平台能够适应有利于阐明自然行为背后的神经机制的生态有效环境，并为神经和精神障碍的可行治疗方法的发展提供支持。
