肝素及其相关产品的制备与合成研究进展。
Advances in the preparation and synthesis of heparin and related products.
机构信息
Department of Chemistry & Chemical Biology, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY, USA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Gazi University, Ankara, Turkey.
Department of Chemistry & Chemical Biology, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY, USA; Department of Chemical and Biological Engineering, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY, USA; Department of Biological Sciences, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY, USA.
出版信息
Drug Discov Today. 2020 Dec;25(12):2095-2109. doi: 10.1016/j.drudis.2020.09.011. Epub 2020 Sep 16.
Heparin is a naturally occurring glycosaminoglycan from livestock, principally porcine intestine, and is clinically used as an anticoagulant drug. A limitation to heparin production is that it depends on a single animal species and potential problems have been associated with animal-derived heparin. The contamination crisis in 2008 led to a search for new animal sources and the investigation of non-animal sources of heparin. Over the past 5 years, new animal sources, chemical, and chemoenzymatic methods have been introduced to prepare heparin-based drugs. In this review, we describe advances in the preparation and synthesis of heparin and related products.
肝素是一种天然存在的糖胺聚糖，主要来自猪的肠道，临床上用作抗凝药物。肝素生产的一个限制因素是它依赖于单一的动物物种，并且与动物来源的肝素有关的潜在问题。2008 年的污染危机导致人们寻找新的动物来源，并研究肝素的非动物来源。在过去的 5 年中，已经引入了新的动物来源、化学和化学酶方法来制备肝素类药物。在这篇综述中，我们描述了肝素及其相关产品的制备和合成方面的进展。
Zotero 插件