Briata Paola, Gherzi Roberto
Gene Expression Regulation Laboratory, Ospedale Policlinico San Martino IRCCS, 16132 Genova, Italy.
Noncoding RNA. 2020 Sep 17;6(3):40. doi: 10.3390/ncrna6030040.
Although mammals possess roughly the same number of protein-coding genes as worms, it is evident that the non-coding transcriptome content has become far broader and more sophisticated during evolution. Indeed, the vital regulatory importance of both short and long non-coding RNAs (lncRNAs) has been demonstrated during the last two decades. RNA binding proteins (RBPs) represent approximately 7.5% of all proteins and regulate the fate and function of a huge number of transcripts thus contributing to ensure cellular homeostasis. Transcriptomic and proteomic studies revealed that RBP-based complexes often include lncRNAs. This review will describe examples of how lncRNA-RBP networks can virtually control all the post-transcriptional events in the cell.
尽管哺乳动物拥有与蠕虫大致相同数量的蛋白质编码基因，但很明显，非编码转录组的内容在进化过程中变得更加广泛和复杂。事实上，在过去二十年中，短链和长链非编码RNA（lncRNA）的重要调控作用已得到证实。RNA结合蛋白（RBP）约占所有蛋白质的7.5%，并调节大量转录本的命运和功能，从而有助于确保细胞内稳态。转录组学和蛋白质组学研究表明，基于RBP的复合物通常包含lncRNA。本综述将举例说明lncRNA-RBP网络如何实际上控制细胞内所有的转录后事件。
