Huang Qiqi, Wang Yi, Gu Binbin, Xu Yanwen
Department of Nutrition, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000 China.
Department of Endocrinology, Huzhou Hospital of Traditional Chinese Medicine, Zhejiang University of Traditional Chinese Medicine, No.315 of South Chaoyang Street, Huzhou, 313000 China.
Diabetol Metab Syndr. 2020 Sep 17;12:81. doi: 10.1186/s13098-020-00582-8. eCollection 2020.
Whether polymorphisms in tumor necrosis factor-α (), interleukin-6 (), interleukin-10 () or adiponectin () influence the risk of gestational diabetes mellitus (GDM) or not remain inconclusive. Therefore, the authors conducted a meta-analysis to robustly assess relationships between polymorphisms in , , or and the risk of GDM by merging the results of eligible publications.
A through literature searching in Medline, Embase, Wanfang, VIP and CNKI was conducted by the authors to identify eligible publications, and twenty-two publications were finally found to be eligible for merged quantitative analyses.
The merged quantitative analyses revealed that + 45T/G (rs2241766) polymorphism was significantly associated with the risk of GDM in overall population (dominant comparison: OR = 0.70, p < 0.001; recessive comparison: OR = 1.95, p < 0.001; over-dominant comparison: OR = 1.18, p = 0.03; allele comparison: OR = 0.71, p < 0.001) and Asians (dominant comparison: OR = 0.70, p < 0.001; recessive comparison: OR = 1.94, p < 0.001; allele comparison: OR = 0.72, p < 0.001). Nevertheless, we did not observe any positive results for - 238G/A (rs361525), - 308G/A (rs1800629), - 174G/C (rs1800795), - 819C/T (rs1800871), - 592C/A (rs1800872), - 1082A/G (rs1800896) and + 276G/T (rs1501299) polymorphisms.
The present meta-analysis shows that among investigated , , or polymorphisms only + 45T/G (rs2241766) polymorphism may affect the risk of GDM.
肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）、白细胞介素-10（IL-10）或脂联素（ADIPOQ）基因多态性是否会影响妊娠期糖尿病（GDM）的发病风险尚无定论。因此，作者进行了一项荟萃分析，通过合并符合条件的出版物结果，以有力地评估TNF-α、IL-6、IL-10或ADIPOQ基因多态性与GDM发病风险之间的关系。
作者通过全面检索Medline、Embase、万方、维普和中国知网数据库来识别符合条件的出版物，最终发现22篇出版物符合纳入定量分析的条件。
合并的定量分析显示，TNF-α +45T/G（rs2241766）多态性与总体人群中GDM的发病风险显著相关（显性模型比较：OR = 0.70，p < 0.001；隐性模型比较：OR = 1.95，p < 0.001；共显性模型比较：OR = 1.18，p = 0.03；等位基因比较：OR = 0.71，p < 0.001），在亚洲人群中也是如此（显性模型比较：OR = 0.70，p < 0.001；隐性模型比较：OR = 1.94，p < 0.001；等位基因比较：OR = 0.72，p < 0.001）。然而，对于IL-6 -238G/A（rs361525）、IL-10 -308G/A（rs1800629）、IL-10 -174G/C（rs1800795）、ADIPOQ -819C/T（rs1800871）、ADIPOQ -592C/A（rs1800872）、ADIPOQ -1082A/G（rs1800896）和ADIPOQ +276G/T（rs1501299）多态性，未观察到任何阳性结果。
本荟萃分析表明，在所研究的TNF-α、IL-6、IL-10或ADIPOQ基因多态性中，只有TNF-α +45T/G（rs2241766）多态性可能影响GDM的发病风险。
