Research Center for Bioengineering and Sensing Technology, Beijing Key Laboratory for Bioengineering and Sensing Technology, Department of Chemistry & Biological Engineering, University of Science & Technology Beijing, Beijing 100083, China.
Soft Matter. 2020 Oct 28;16(41):9553-9558. doi: 10.1039/d0sm01355b.
Hybrid micro/nanomotors with multiple distinct propulsion modes are expected to improve their motion ability in complex body fluids. Herein, we report a multi-stimuli propelled Janus lipase-modified dendritic silica/carbon@Pt (DMS/C@Pt) nanomotor with built-in engines for hybrid propulsions of H2O2, light, and enzyme. The enhanced motion of the DMS/C@Pt nanomotor is achieved under the stimulus of H2O2 that produces an oxygen concentration gradient derived from the asymmetric catalysis of Pt nanoparticles. Irradiated with near-infrared (NIR) light, the uneven photothermal effect of the carbon part propels this nanomotor by self-thermophoresis. Besides, lipase is efficiently loaded into the dendritic pores, which decomposes triglyceride on the silica part and induces self-diffusiophoretic propulsion. These multiple propulsions shed light on the rational integration of various functional building blocks into one micro/nanomotor for complex tasks in biomedical applications.
具有多种不同推进模式的混合微/纳米马达有望提高其在复杂体液中的运动能力。在此，我们报道了一种多刺激推进的介孔硅/碳@铂（DMS/C@Pt）树枝状纳米马达，该马达修饰有 Janus 脂肪酶，内置了 H2O2、光和酶的混合推进引擎。在 H2O2 的刺激下，纳米马达通过 Pt 纳米粒子的不对称催化产生氧气浓度梯度，从而实现增强的运动。近红外（NIR）光的照射会引起碳部分的非均匀光热效应，从而通过自热泳推动纳米马达。此外，脂肪酶被有效地装载到树枝状孔隙中，在那里分解硅部分上的三酰基甘油，并诱导自扩散推进。这些多种推进方式为将各种功能构建块合理地整合到一个微/纳米马达中，以用于生物医学应用中的复杂任务提供了思路。
