Li Qingqing, Liu Luntao, Huo Hongqi, Su Lichao, Wu Ying, Lin Hongxin, Ge Xiaoguang, Mu Jing, Zhang Xuan, Zheng Liting, Song Jibin
Fujian Science & Technology Innovation Laboratory for Optoelectronic Information of China, MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, College of Chemical Engineering, Fuzhou University, Fuzhou 350108, P. R. China.
Department of Nuclear Medicine, Han Dan Central Hospital, Handan, Hebei 056001, P. R. China.
ACS Nano. 2022 May 24;16(5):7947-7960. doi: 10.1021/acsnano.2c00732. Epub 2022 May 10.
Synthetic micro/nanomotors have great potential in deep tissue imaging and drug delivery because of their active motion ability. However, applying nanomotors with a size less than 100 nm to imaging and therapy is one of the core changes in this field. Herein, a nanosized hydrogen peroxide (HO)-driven Janus gold nanorod-platinum (JAuNR-Pt) nanomotor is developed for enhancing the second near-infrared region (NIR-II) photoacoustic (PA) imaging of deep tissues of tumors and for effective tumor treatment. The JAuNR-Pt nanomotor is prepared by depositing platinum (Pt) on one end of a gold nanorod with varying proportions of Pt shell coverage, including 10%, 25%, 50%, 75%, and 100%. The JAuNR-Pt nanomotor with Pt shell coverage proportions of 50% exhibits the highest diffusion coefficient (), and it can rapidly move in the presence of HO. The self-propulsion of JAuNR-Pt nanomotor enhances cellular uptake, accelerates lysosomal escape, and facilitates continuous release of cytotoxic Pt ions to the nucleus, causing DNA damage and cell apoptosis. The JAuNR-Pt nanomotor presents deep penetration and enhanced accumulation in tumors as well as high tumor treatment effect. Therefore, this work displays deep tumor imaging and an excellent antitumor effect, providing an effective tool for accurate diagnosis and treatment of diseases.
合成微纳马达因其主动运动能力在深部组织成像和药物递送方面具有巨大潜力。然而，将尺寸小于100 nm的纳米马达应用于成像和治疗是该领域的核心变革之一。在此，开发了一种纳米级过氧化氢（H₂O₂）驱动的Janus金纳米棒-铂（JAuNR-Pt）纳米马达，用于增强肿瘤深部组织的二次近红外区域（NIR-II）光声（PA）成像以及有效治疗肿瘤。通过在金纳米棒的一端沉积铂（Pt）来制备JAuNR-Pt纳米马达，铂壳覆盖比例各不相同，包括10%、25%、50%、75%和100%。铂壳覆盖比例为50%的JAuNR-Pt纳米马达表现出最高的扩散系数（），并且在H₂O₂存在的情况下能够快速移动。JAuNR-Pt纳米马达的自推进增强了细胞摄取，加速了溶酶体逃逸，并促进了细胞毒性铂离子持续释放到细胞核，导致DNA损伤和细胞凋亡。JAuNR-Pt纳米马达在肿瘤中表现出深度穿透和增强的聚集以及高肿瘤治疗效果。因此，这项工作展示了深部肿瘤成像和出色的抗肿瘤效果，为疾病的准确诊断和治疗提供了一种有效工具。
