Department of Cardiology, The Second People's Hospital of Chengdu, Chengdu, Sichuan, China.
Department of Epidemiology and Health Statistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China.
Sci Rep. 2020 Sep 24;10(1):15683. doi: 10.1038/s41598-020-72780-3.
Hyperuricemia is prevalent throughout the world. However, a well-designed large-scale epidemiological investigation of hyperuricemia in southwestern China is lacking. A regional representative sample of 10,141 participants were included using multistage, stratified sampling in Chengdu and Chongqing from September 2013 to March 2014. Hyperuricemia was defined as the self-reported of the doctor's diagnosis of hyperuricemia, or serum uric acid > 420 μmol/L in men or serum uric acid > 360 μmol/L in women. The overall age- and sex-standardized prevalence of hyperuricemia among adults aged 35-79 years was 13.5%. Compared with women, the prevalence of hyperuricemia in men was higher (17.3% versus 10.0%). Hypertension, hyperlipidemia, overweight or obesity, central obesity were associated with an increased risk for hyperuricemia both in men and in women. Married men and women were not susceptible to hyperuricemia. Current cigarette smoking was an associated risk factor of hyperuricemia only in women. Hyperuricemia has become a major health problem among urban adults aged 35-79 years in southwestern China, and special attention should be paid to men. Comorbidities associated with hyperuricemia and causality worth further investigation.
高尿酸血症在全球范围内普遍存在。然而，中国西南部缺乏针对高尿酸血症的精心设计的大规模流行病学调查。2013 年 9 月至 2014 年 3 月，采用多阶段、分层抽样方法，在成都和重庆选取了 10141 名具有区域代表性的参与者。高尿酸血症的定义为自我报告的医生诊断高尿酸血症，或男性血清尿酸>420μmol/L，女性血清尿酸>360μmol/L。35-79 岁成年人中高尿酸血症的总年龄和性别标准化患病率为 13.5%。与女性相比，男性高尿酸血症的患病率更高（17.3%对 10.0%）。高血压、高血脂、超重或肥胖、中心性肥胖在男性和女性中均与高尿酸血症的风险增加相关。已婚男性和女性不易患高尿酸血症。目前吸烟是女性高尿酸血症的一个相关危险因素。高尿酸血症已成为中国西南部 35-79 岁城市成年人的一个主要健康问题，应特别关注男性。与高尿酸血症相关的合并症和因果关系值得进一步研究。
