Lin Ruyi, Yu Wenqi, Chen Xianchun, Gao Huile
College of Materials Science and Engineering, Sichuan University, Chengdu, 610064, P. R. China.
Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu, 610064, P. R. China.
Adv Healthc Mater. 2021 Jan;10(1):e2001212. doi: 10.1002/adhm.202001212. Epub 2020 Sep 25.
Cancer is still one of the most serious diseases with threats to health and life. Although some advances have been made in targeting delivery of antitumor drugs over the past number of years, there are still many problems needing to be solved, such as poor efficacy and high systemic toxicity. Micro/nanomotors capable of self-propulsion in fluid provide promising platforms for improving the efficiency of tumor delivery. Herein, the recent progress in micro/nanomotors for tumor targeting delivery and therapy is reviewed, with special focus on the contributions of micro/nanomotors to the different stages of tumor targeting delivery as well as the combination therapy by micro/nanomotors. The present limitations and future directions are also put forward for further development.
癌症仍然是对健康和生命构成威胁的最严重疾病之一。尽管在过去几年中，抗肿瘤药物的靶向递送取得了一些进展，但仍有许多问题需要解决，例如疗效不佳和全身毒性高。能够在流体中自行推进的微纳马达为提高肿瘤递送效率提供了有前景的平台。在此，综述了用于肿瘤靶向递送和治疗的微纳马达的最新进展，特别关注微纳马达对肿瘤靶向递送不同阶段的贡献以及微纳马达的联合治疗。还提出了当前的局限性和未来的发展方向以供进一步发展。
