Department of Chemistry and Biochemistry, University of California, 1156 High Street, Santa Cruz, California, 95064, United States.
Chem Rec. 2020 Dec;20(12):1505-1515. doi: 10.1002/tcr.202000090. Epub 2020 Sep 25.
Conventional β-lactam antibiotics are resisted by bacteria at an increasing rate, prompting studies into the development of alternate antibiotic agents. In this personal account, we summarize recent progress in the design and engineering of graphene oxide quantum dot-based nanomaterials as potent antimicrobial agents. Specifically, we examine the impacts of chemical reduction on the antimicrobial activity of graphene oxide quantum dots, and enhancement of the bactericidal performance by the formation of nanocomposites with metal oxide nanoparticles, within the context of photodynamic generation of reactive oxygen species. A perspective is also included where the promises and challenges are highlighted in the development of high-performance antimicrobial agents based on graphene derivatives.
传统的β-内酰胺类抗生素的耐药性在不断增加,促使人们研究开发替代抗生素。在这篇个人述评中,我们总结了基于氧化石墨烯量子点的纳米材料作为有效抗菌剂的设计和工程方面的最新进展。具体而言,我们研究了化学还原对氧化石墨烯量子点抗菌活性的影响,以及通过与金属氧化物纳米粒子形成纳米复合材料来提高杀菌性能,同时探讨了在活性氧产生的光动力条件下的情况。文中还包括了基于石墨烯衍生物开发高性能抗菌剂的前景和挑战。