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Androgen receptor genetic variant predicts COVID-19 disease severity: a prospective longitudinal study of hospitalized COVID-19 male patients.

作者信息

McCoy J, Wambier C G, Herrera S, Vaño-Galván S, Gioia F, Comeche B, Ron R, Serrano-Villar S, Iwasiow R M, Tayeb M A, Cadegiani F A, Mesinkovska N A, Shapiro J, Sinclair R, Goren A

机构信息

Applied Biology, Inc., Irvine, CA, USA.

Department of Dermatology, Alpert Medical School of Brown University, Providence, RI, USA.

出版信息

J Eur Acad Dermatol Venereol. 2021 Jan;35(1):e15-e17. doi: 10.1111/jdv.16956. Epub 2020 Oct 21.

DOI:10.1111/jdv.16956
PMID:32977355
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7536899/
Abstract
摘要

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本文引用的文献

1
Sex hormones signal why virus hits men harder.性激素揭示病毒为何对男性影响更大。
Science. 2020 Jun 5;368(6495):1038-1039. doi: 10.1126/science.368.6495.1038.
2
Impact of sex and gender on COVID-19 outcomes in Europe.欧洲 COVID-19 结局的性别差异。
Biol Sex Differ. 2020 May 25;11(1):29. doi: 10.1186/s13293-020-00304-9.
3
Androgenetic alopecia present in the majority of patients hospitalized with COVID-19: The "Gabrin sign".雄激素性脱发在大多数因新冠肺炎住院的患者中出现：“加布林征” 。
J Am Acad Dermatol. 2020 Aug;83(2):680-682. doi: 10.1016/j.jaad.2020.05.079. Epub 2020 May 22.
4
Androgen sensitivity gateway to COVID-19 disease severity.雄激素敏感性是 COVID-19 疾病严重程度的关键。
Drug Dev Res. 2020 Nov;81(7):771-776. doi: 10.1002/ddr.21688. Epub 2020 May 15.
5
Androgen-deprivation therapies for prostate cancer and risk of infection by SARS-CoV-2: a population-based study (N = 4532).雄激素剥夺疗法治疗前列腺癌与 SARS-CoV-2 感染风险的关系：一项基于人群的研究（N=4532）。
Ann Oncol. 2020 Aug;31(8):1040-1045. doi: 10.1016/j.annonc.2020.04.479. Epub 2020 May 6.
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Influence of CAG Repeat Polymorphism on the Targets of Testosterone Action.CAG重复多态性对睾酮作用靶点的影响。
Int J Endocrinol. 2015;2015:298107. doi: 10.1155/2015/298107. Epub 2015 Sep 2.
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Protein arginine methyltransferase 6 enhances polyglutamine-expanded androgen receptor function and toxicity in spinal and bulbar muscular atrophy.蛋白质精氨酸甲基转移酶6增强脊髓延髓性肌萎缩症中多聚谷氨酰胺扩展的雄激素受体功能及毒性。
Neuron. 2015 Jan 7;85(1):88-100. doi: 10.1016/j.neuron.2014.12.031.
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Androgen receptor polyglutamine repeat length affects receptor activity and C2C12 cell development.雄激素受体多聚谷氨酰胺重复长度影响受体活性和 C2C12 细胞发育。
Physiol Genomics. 2011 Oct 20;43(20):1135-43. doi: 10.1152/physiolgenomics.00049.2011. Epub 2011 Aug 9.
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Androgen receptor (AR) coregulators: a diversity of functions converging on and regulating the AR transcriptional complex.雄激素受体（AR）共调节因子：多种功能汇聚并调节AR转录复合物。
Endocr Rev. 2007 Dec;28(7):778-808. doi: 10.1210/er.2007-0019. Epub 2007 Oct 16.