Bagheri Hesam Saghaei, Bani Farhad, Tasoglu Savas, Zarebkohan Amir, Rahbarghazi Reza, Sokullu Emel
School of Medicine, Biophysics Department, Koç University, Rumeli Fener, Sarıyer, Istanbul, Turkey.
Koç University Translational Medicine Research Center (KUTTAM) Rumeli Feneri, Sarıyer, Istanbul, Turkey.
J Transl Med. 2020 Sep 25;18(1):367. doi: 10.1186/s12967-020-02529-z.
The existence of active crosstalk between cells in a paracrine and juxtacrine manner dictates specific activity under physiological and pathological conditions. Upon juxtacrine interaction between the cells, various types of signaling molecules and organelles are regularly transmitted in response to changes in the microenvironment. To date, it has been well-established that numerous parallel cellular mechanisms participate in the mitochondrial transfer to modulate metabolic needs in the target cells. Since the conception of stem cells activity in the restoration of tissues' function, it has been elucidated that these cells possess a unique capacity to deliver the mitochondrial package to the juxtaposed cells. The existence of mitochondrial donation potentiates the capacity of modulation in the distinct cells to achieve better therapeutic effects. This review article aims to scrutinize the current knowledge regarding the stem cell's mitochondrial transfer capacity and their regenerative potential.
细胞间以旁分泌和近分泌方式进行的活跃串扰的存在，决定了生理和病理条件下的特定活性。细胞间发生近分泌相互作用时，各种类型的信号分子和细胞器会根据微环境的变化而有规律地传递。迄今为止，已经明确有许多平行的细胞机制参与线粒体转移，以调节靶细胞的代谢需求。自干细胞活性在组织功能恢复中的概念提出以来，已经阐明这些细胞具有将线粒体包裹传递给相邻细胞的独特能力。线粒体捐赠的存在增强了不同细胞的调节能力，以实现更好的治疗效果。这篇综述文章旨在审视关于干细胞线粒体转移能力及其再生潜力的现有知识。
