Hernando-Amado Sara, Coque Teresa M, Baquero Fernando, Martínez José L
Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain.
Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS) and Centro de Investigación Biomédica en Red Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.
Front Microbiol. 2020 Aug 28;11:1914. doi: 10.3389/fmicb.2020.01914. eCollection 2020.
Antibiotic resistance is a problem for human health, and consequently, its study had been traditionally focused toward its impact for the success of treating human infections in individual patients (individual health). Nevertheless, antibiotic-resistant bacteria and antibiotic resistance genes are not confined only to the infected patients. It is now generally accepted that the problem goes beyond humans, hospitals, or long-term facility settings and that it should be considered simultaneously in human-connected animals, farms, food, water, and natural ecosystems. In this regard, the health of humans, animals, and local antibiotic-resistance-polluted environments should influence the health of the whole interconnected local ecosystem (One Health). In addition, antibiotic resistance is also a global problem; any resistant microorganism (and its antibiotic resistance genes) could be distributed worldwide. Consequently, antibiotic resistance is a pandemic that requires Global Health solutions. Social norms, imposing individual and group behavior that favor global human health and in accordance with the increasingly collective awareness of the lack of human alienation from nature, will positively influence these solutions. In this regard, the problem of antibiotic resistance should be understood within the framework of socioeconomic and ecological efforts to ensure the sustainability of human development and the associated human-natural ecosystem interactions.
抗生素耐药性是人类健康面临的一个问题,因此,传统上对其研究一直聚焦于其对个体患者治疗人类感染成功与否的影响(个体健康)。然而,耐抗生素细菌和抗生素耐药基因并不局限于受感染的患者。现在人们普遍认为,这个问题超出了人类、医院或长期护理机构的范畴,而且应该在与人类相关的动物、农场、食物、水和自然生态系统中同时加以考虑。在这方面,人类、动物以及当地受抗生素耐药性污染的环境的健康状况应该会影响整个相互关联的当地生态系统的健康(同一健康理念)。此外,抗生素耐药性也是一个全球性问题;任何耐药微生物(及其抗生素耐药基因)都可能在全球范围内传播。因此,抗生素耐药性是一种需要全球健康解决方案的大流行病。社会规范规定了有利于全球人类健康的个人和群体行为,并且符合人们日益增强的集体意识,即认识到人类与自然并非相互疏离,这将对这些解决方案产生积极影响。在这方面,抗生素耐药性问题应该在社会经济和生态努力的框架内加以理解,以确保人类发展以及相关的人类 - 自然生态系统相互作用的可持续性。