Combined donor-recipient genotypes of leptin receptor and adiponectin gene polymorphisms affect the incidence of complications after renal transplantation.

BACKGROUND

We aimed to examine whether combined donor/recipient variants in the leptin receptor () and adiponectin () genes may affect outcomes in renal transplantation.

METHODS

A total of 233 donors and their corresponding 307 recipients were genotyped for rs1805094, rs1137100 and rs1137101, and rs1501299 and rs224176. Combined donor/recipient genetic scores were created to investigate associations with delayed graft function (DGF), graft loss and estimated glomerular filtration rate (eGFR).

RESULTS

Recipients whose donors carried variant alleles of and rs1137101 had lower risk of DGF [OR = 0.48 (0.24-0.97),  = 0.040] and [OR = 0.47 (0.23-0.95),  = 0.035], respectively. In addition, rs1137101 also showed an inverse association with lower incidence of graft loss [OR = 0.44 (0.31-0.97),  = 0.040]. The analysis of genetic scores of donor/recipients showed that again rs1137101 was inversely associated with both outcomes: OR = 0.46 (0.23-0.92),  = 0.029 and OR = 0.45 (0.11-0.81),  = 0.009, respectively. With regard to graft function, the T-allele of rs1501299 in the donor was related to higher eGFR values (75.26 ± 29.01 vs. 67.34 ± 25.39 ml/min for wild-type grafts,  = 0.012). Higher combined genetic scores in this same polymorphism were also associated with better function (78.33 ± 31.87 vs. 68.25 ± 24.32 ml/min,  = 0.018). Finally, eGFR values were similar between paired kidneys but they were different when comparing grafts with or without the rs1501299 T-variant (77.87 ± 26.50 vs. 69.27 ± 26.73 ml/min,  = 0.016).

CONCLUSIONS

Our study has shown for the first time to our knowledge that variants in and genes of the donors and/or their combination with those in the recipients may affect the outcome of renal transplantation.