Kalsotra Gopika, Saraf Aditiya, Raina Apurva, Kalsotra Parmod, Sharma Rupali, Hussain Abid
Department of Otorhinolaryngology, Smgs Hospital, Gmc Jammu, J&K India.
Indian J Otolaryngol Head Neck Surg. 2022 Dec;74(Suppl 3):4676-4679. doi: 10.1007/s12070-021-03004-x. Epub 2022 Jan 5.
Allergic rhinitis is a common and chronic immunoglobulin E-mediated inflammation of nasal mucosa induced after allergen exposure. Allergic rhinitis is a global health problem that causes major illness and affects patient's social life, sleep, school and work performance. Various studies have implicated the association between low serum vitamin D levels and allergic diseases. Active form of Vitamin D3 has been shown to have immunoregulatory effect on both innate and adaptive immunity, which can significantly affect the outcome of allergic responses in allergic rhinitis. The study aims to evaluate effectiveness of Oral Vitamin D3 supplementation as an adjunct to standard therapy, in the management of allergic rhinitis. The present study is a prospective study in which 80 subjects were recruited and were randomly divided into two groups. The study group received oral vitamin D3 (60,000 IU) along with intranasal steroid spray while control group received only intranasal steroid spray for 4 weeks. The response in both the groups was compared by evaluating total nasal symptom score (TNSS). Subjects of allergic rhinitis showed deficiency in vitamin D indicated by mean serum vitamin D levels of 15 ± 2.42 ng/ml in the study group and 14.72 ± 2.64 ng/ml in the control group. The pre treatment mean TNSS score was 10.45 ± 3.1 in the study group and 11.43 ± 2.35 in the control group. The post treatment mean TNSS score was 2.1 ± 0.21 in the study group and 3.85 ± 0.76 in the control group. A significant reduction in symptoms score was observed after 4 weeks of oral vitamin D3 supplementation. The difference between two groups was found to be statistically significant ( value < 0.05).
变应性鼻炎是一种常见的慢性免疫球蛋白E介导的鼻黏膜炎症，由接触变应原后诱发。变应性鼻炎是一个全球性的健康问题，可导致严重疾病，并影响患者的社交生活、睡眠、学业和工作表现。各种研究表明血清维生素D水平低与变应性疾病之间存在关联。维生素D3的活性形式已被证明对固有免疫和适应性免疫均具有免疫调节作用，这可显著影响变应性鼻炎变应性反应的结果。本研究旨在评估口服补充维生素D3作为标准治疗辅助手段在变应性鼻炎管理中的有效性。本研究是一项前瞻性研究，招募了80名受试者并将其随机分为两组。研究组接受口服维生素D3（60,000 IU）及鼻内用类固醇喷雾剂，而对照组仅接受鼻内用类固醇喷雾剂，为期4周。通过评估总鼻症状评分（TNSS）比较两组的反应。变应性鼻炎受试者显示维生素D缺乏，研究组平均血清维生素D水平为15±2.42 ng/ml，对照组为14.72±2.64 ng/ml。治疗前研究组平均TNSS评分为10.45±3.1，对照组为11.43±2.35。治疗后研究组平均TNSS评分为2.1±0.21，对照组为3.85±0.76。口服维生素D3补充4周后观察到症状评分显著降低。发现两组之间的差异具有统计学意义（P值<0.05）。
