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接触结晶二氧化硅的混凝土工人肺功能指标变化与肺癌死亡率的估计

Changes in Spirometry Indices and Lung Cancer Mortality Risk Estimation in Concrete Workers Exposed io Crystalline Silica.

机构信息

Department of Occupational Health Engineering, Neyshabur University of Medical Sciences, Neyshabur, Iran.

Environmental Health Engineering Research Center, Kerman University of Medical Sciences, Kerman, Iran.

出版信息

Asian Pac J Cancer Prev. 2020 Sep 1;21(9):2811-2817. doi: 10.31557/APJCP.2020.21.9.2811.

Abstract

The health of workers in the concrete and cement industries can be at risk due to occupational exposure to silica dust. The purpose of this study was to evaluate the changes of pulmonary parameters and risk of mortality from lung cancer in concrete workers exposed to crystalline silica. This cross-sectional study was performed on 72 male workers exposed to silica at a concrete manufacturing plant in Neyshabur, Iran. Respiratory zone air sampling was performed using the standard NIOSH7602 method using individual sampling pumps and membrane filters. Then, the amount of silica in the samples was determined using the Fourier Transform Infrared technique. The risk of death from lung cancer was determined using Rice et al.'s model. Respiratory indices were measured using a spirometer. Data were analyzed by the SPSS 20 software. Occupational exposure to silica was 0.025 mg/m3 and mortality was estimated to be 7-94 per thousand. All spirometry indices significantly decreased during these 4 years of exposure to silica dust. The respiratory pattern of 22% of the exposed workers was obstructive and this prevalence was significantly higher than the control group. The results showed that although the average occupational exposure to silica in these concrete workers was below the recommended threshold of national and international organizations, their risk of death was significantly higher; and workers' lung indices had significantly decreased over four years. Therefore, appropriate measures should be taken to reduce silica exposure among these workers.

摘要

由于职业暴露于二氧化硅粉尘,混凝土和水泥行业工人的健康可能会受到威胁。本研究旨在评估暴露于结晶二氧化硅的混凝土工人的肺功能参数变化和肺癌死亡率风险。这项横断面研究在伊朗内沙布尔的一家混凝土制造厂对 72 名男性工人进行,他们暴露于二氧化硅。使用个体采样泵和膜过滤器,采用美国国家职业安全卫生研究所(NIOSH)的标准 7602 方法进行呼吸区空气采样。然后,使用傅里叶变换红外技术测定样品中的二氧化硅含量。使用 Rice 等人的模型确定肺癌死亡风险。使用肺活量计测量呼吸指数。使用 SPSS 20 软件对数据进行分析。职业性二氧化硅暴露为 0.025mg/m3,死亡率估计为千分之 7-94。在接触二氧化硅粉尘的这 4 年中,所有肺活量指数均显著下降。22%的暴露工人的呼吸模式为阻塞性,这一患病率明显高于对照组。结果表明,尽管这些混凝土工人的平均职业性二氧化硅暴露量低于国家和国际组织推荐的阈值,但他们的死亡风险显著增加;并且工人的肺功能指数在四年内显著下降。因此,应采取适当措施降低这些工人的二氧化硅暴露。

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