East China Normal University and Shanghai Changzheng Hospital Joint Research Center for Orthopedic Oncology, 200241, Shanghai, China; Department of Orthopedics Oncology, Changzheng Hospital, Navy Medical University, Shanghai, 200003, China.
East China Normal University and Shanghai Changzheng Hospital Joint Research Center for Orthopedic Oncology, 200241, Shanghai, China; Department of Orthopedics Oncology, Changzheng Hospital, Navy Medical University, Shanghai, 200003, China.
Biomaterials. 2021 Jan;265:120404. doi: 10.1016/j.biomaterials.2020.120404. Epub 2020 Sep 22.
A variety of targeted nanoparticles were developed for the diagnosis and therapy of orthotopic and metastatic bone tumors during the past decade. This critical review will focus on principles and methods in the design of these bone-targeted nanoparticles. Ligands including bisphosphonates, aspartic acid-rich peptides and synthetic polymers were grafted on nanoparticles such as PLGA nanoparticles, liposomes, dendrimers and inorganic nanoparticles for bone targeting. Besides, other ligands such as monoclonal antibodies, peptides and aptamers targeting biomarkers on tumor/bone cells were identified for targeted diagnosis and therapy. Examples of targeted nanoparticles for the early detection of bone metastatic tumors and the ablation of cancer via chemotherapy, photothermal therapy, gene therapy and combination therapy will be intensively reviewed. The development of multifunctional nanoparticles to break down the "vicious" cycle between tumor cell proliferation and bone resorption, and the challenges and perspectives in this area will be discussed.
在过去十年中，开发了多种针对原位和转移性骨肿瘤的靶向纳米粒子，用于诊断和治疗。本综述将重点介绍这些骨靶向纳米粒子的设计原理和方法。配体包括双膦酸盐、富含天冬氨酸的肽和合成聚合物，被接枝到纳米粒子上，如 PLGA 纳米粒子、脂质体、树枝状聚合物和无机纳米粒子，以实现骨靶向。此外，还鉴定了其他配体，如针对肿瘤/骨细胞上生物标志物的单克隆抗体、肽和适体，用于靶向诊断和治疗。将重点综述用于早期检测骨转移瘤和通过化学疗法、光热疗法、基因疗法和联合疗法消融癌症的靶向纳米粒子的例子。还将讨论多功能纳米粒子的发展以打破肿瘤细胞增殖和骨吸收之间的“恶性循环”，以及该领域的挑战和展望。
