El-Attar Rehab O, Abdelhameed Reda M, Khaled Elmorsy
Microanalysis Laboratory, Applied Organic Chemistry Department, National Research Centre, El Bohouth St., Dokki, Giza, 12622, Egypt.
Applied Organic Chemistry Department, National Research Center, El Bohouth St., Dokki, Giza, 12622, Egypt.
BMC Chem. 2025 May 29;19(1):150. doi: 10.1186/s13065-025-01521-2.
Screen-printing is a well-established promising technology for large scale production of planner disposable electrochemical sensors. The present study aims to fabricate a novel donepezil hydrochloride (DPH) screen-printed sensor integrated with the cross-linked β-cyclodextrin-functionalized aluminum metal organic framework-multiwall carbon nanotubes nanocomposites (β-CD/MOF/MWCNTs) as a novel sensing element. The fabricated disposable sensors exhibit theoretical Nernstian compliance value of 60.7 ± 1.5 mV decade within a linear dynamic concentration range from 10 to 10 mol L and limit of detection 7.0 × 10 molL. The DPH disposable sensors show high potential stability with a prolonged operational lifetime and the fast response time of 6 s. The presented electrochemical sensors represent an efficient analytical tool for fast and sensitive assay of DPH residues in the marketed pharmaceutical tablets and biological samples with acceptable average recoveries under direct potentiometric measurements, flow injection analysis (FIA), and potentiometric titration. Moreover, the dissolution and degradation studies of DPH can be monitored by the presented disposable sensors.
丝网印刷是一种成熟的、有前景的用于大规模生产平面一次性电化学传感器的技术。本研究旨在制造一种新型盐酸多奈哌齐（DPH）丝网印刷传感器，该传感器集成了交联的β-环糊精功能化铝金属有机框架-多壁碳纳米管纳米复合材料（β-CD/MOF/MWCNTs）作为新型传感元件。所制备的一次性传感器在10至10 mol/L的线性动态浓度范围内表现出理论能斯特响应值为60.7±1.5 mV/十倍浓度变化，检测限为7.0×10 mol/L。DPH一次性传感器具有高电位稳定性、延长的使用寿命和6秒的快速响应时间。所提出的电化学传感器是一种高效的分析工具，可用于在直接电位测量、流动注射分析（FIA）和电位滴定下，对市售药片中的DPH残留和生物样品进行快速、灵敏的测定，平均回收率可接受。此外，所提出的一次性传感器可用于监测DPH的溶解和降解研究。
