Department of International Island and Community Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, 890-8544, Japan.
Division of Nursing, Faculty of Nursing, Tokyo Healthcare University, Tokyo, 152-8558, Japan.
Alcohol. 2020 Dec;89:129-138. doi: 10.1016/j.alcohol.2020.09.002. Epub 2020 Sep 28.
To investigate the association between alcohol intake pattern in amount and frequency and metabolic syndrome (Mets) components, we simulated the change in the prevalence of Mets components by intake reduction. In order to manage Mets, alcohol intake reduction with moderation of intake pattern is required. However, evidence investigating the comparative impact of alcohol intake reduction in amount and frequency for Mets components is limited. We conducted a large-scale cross-sectional study in the general Japanese population. The study subjects included 37,371 non-drinkers and current drinkers recruited in the Japan Multi-Institutional Collaborative Cohort Study. Odds ratios (ORs) for Mets components according to alcohol intake amount and frequency were estimated using a multiple logistic regression model. The prevalence of Mets components was estimated after assumed alcohol intake reduction of a) none, b) 10 g/day (men) or 5 g/day (women), c) 20 g/day (men) or 10 g/day (women), d) less than 20 g/day (men) or 10 g/day (women) for moderate-to-heavy drinkers, e) 1-2 times/week, and f) 3-4 times/week. The ORs with alcohol intake amount and frequency increased with high blood pressure while decreasing with dyslipidemia. A J-shaped association was observed between intake amount and Mets. The estimated prevalence (%) of high blood pressure and dyslipidemia in men were a) 45.2, b) 43.0, c) 41.4, d) 40.4, e) 42.9, and f) 42.0; and a) 50.3, b) 51.8, c) 52.9, d) 50.2, e) 52.7, and f) 53.4 in women. The estimated prevalence of high blood pressure in women did not evidently decrease. Simulated alcohol intake reduction showed decreased prevalence for high blood pressure and increased prevalence for dyslipidemia in men after reduced intake amount and frequency. The largest decreased prevalence for high blood pressure was observed in men when all moderate-to-heavy drinkers reduced their alcohol intake amount to less than 20 g/day.
为了探究饮酒量和饮酒频率与代谢综合征（Mets）各组分之间的关系，我们通过减少摄入量来模拟 Mets 各组分的患病率变化。为了控制 Mets，需要减少饮酒量并适度调整饮酒模式。然而，目前有关减少饮酒量和饮酒频率对 Mets 各组分影响的证据有限。我们在日本一般人群中进行了一项大规模的横断面研究。研究对象包括在日本多机构合作队列研究中招募的 37371 名非饮酒者和当前饮酒者。使用多因素逻辑回归模型估算了 Mets 各组分与饮酒量和饮酒频率之间的比值比（OR）。在假设减少饮酒量后，估计了 Mets 各组分的患病率：a）不减少，b）减少 10g/天（男性）或 5g/天（女性），c）减少 20g/天（男性）或 10g/天（女性），d）减少中重度饮酒者的饮酒量至<20g/天（男性）或<10g/天（女性），e）减少至每周 1-2 次，f）减少至每周 3-4 次。随着高血压患病率的增加，饮酒量和饮酒频率的 OR 值增加，而随着血脂异常患病率的降低，OR 值降低。饮酒量与 Mets 之间呈 J 形关联。男性高血压和血脂异常的预计患病率（%）为：a）45.2，b）43.0，c）41.4，d）40.4，e）42.9，f）42.0；以及 a）50.3，b）51.8，c）52.9，d）50.2，e）52.7，f）53.4。女性高血压的预计患病率并未明显下降。模拟饮酒量减少显示，男性高血压的患病率降低，血脂异常的患病率增加，这是由于饮酒量和饮酒频率减少所致。所有中重度饮酒者将饮酒量减少至<20g/天时，男性高血压的患病率降幅最大。
