Radboud Center for Infectious Diseases, Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, the Netherlands.
Clarity Pharma Research LLC, Spartanburg, SC, USA.
Respir Med. 2020 Nov;173:106164. doi: 10.1016/j.rmed.2020.106164. Epub 2020 Sep 21.
Nontuberculous mycobacterial pulmonary disease (NTM-PD) is an emerging opportunistic infection, but basic epidemiological data are lacking in most regions. We have investigated epidemiology and diagnostic and treatment practices in five EU countries (United Kingdom, Spain, Italy, France, Germany; EU5) and Japan.
and methods: Annual prevalence in each country was established using a 2-round Delphi method in combination with a regional prevalence-estimation model that incorporated data obtained from a blinded physician screening survey (3154 physicians) and a real-world NTM-PD treating-physician/patient-chart observational study (619 physicians - 1429 patient charts).
The annual prevalence of NTM-PD was estimated at 6.2/100,000 in the EU5 and 24.9/100,000 in Japan. Overall prevalence between the EU5 was comparable, while differences in regional prevalence were found to be pronounced in France and The United Kingdom. Regional differences were also found in Japan, with the majority of cases in Chubu and Kanto regions.
This new methodology for obtaining often missing regional-level epidemiological data reveals dramatic variations in NTM-PD annual prevalence and helps pinpoint areas that may merit special preventative and treatment focus.
非结核分枝杆菌肺病（NTM-PD）是一种新出现的机会性感染，但大多数地区缺乏基本的流行病学数据。我们调查了五个欧盟国家（英国、西班牙、意大利、法国、德国；EU5）和日本的流行病学以及诊断和治疗实践。
使用两轮 Delphi 方法结合区域流行率估算模型，结合来自盲法医生筛查调查（3154 名医生）和真实世界 NTM-PD 治疗医生/患者图表观察性研究（619 名医生-1429 名患者图表）的数据，确定每个国家的年度流行率。
欧盟 5 国的 NTM-PD 年患病率估计为 6.2/100,000，日本为 24.9/100,000。欧盟 5 国之间的总体患病率相当，但在法国和英国发现区域患病率存在明显差异。在日本也发现了区域差异，主要病例集中在中部和关东地区。
这种获取经常缺失的区域水平流行病学数据的新方法揭示了 NTM-PD 年患病率的巨大差异，并有助于确定可能需要特别预防和治疗关注的领域。
