Vegetable Food Technology Department, Kemerovo State University, Krasnaya Street 6, 650043 Kemerovo, Russia.
Institute of Living Systems, Immanuel Kant Baltic Federal University, A. Nevskogo Street 14, 236016 Kaliningrad, Russia.
Nutrients. 2020 Sep 25;12(10):2941. doi: 10.3390/nu12102941.
Dietary supplementation based on sea buckthorn and rosehip oils with added chokeberry extract was studied. We added the dietary supplement to the feed mixtures for laboratory animals. The possible toxicological effects and hypocholesterolemic, hepatoprotective activity of the dietary supplement in vivo were studied. After the observation period (6 weeks), no significant changes were found in the mass of organs and blood serum of laboratory animals ( > 0.05). However, there was a decrease in hypercholesterolemic indicators. Regular consumption of sea buckthorn and rosehip oils with added chokeberry extract (dietary supplement "ESB-1") by laboratory animals inhibited the activity of liver enzymes and increased the antioxidant activity of blood serum (after the subcutaneous injection of sunflower oil/oil solution of carbon tetrachloride) but was not sufficient to bring them to physiological standards. The hypocholesterolemic and antioxidant properties of our dietary supplement already allow us to consider it a component of functional food products or a dietary supplement base. However, the full range of its biologically active properties, including the hepatoprotective function and regulation of metabolic disorders, has not been studied yet, which sets the direction of further research in vivo models and clinical practice to confirm its effectiveness in humans.
以沙棘和玫瑰果油为基础，添加黑加仑提取物的膳食补充剂进行了研究。我们将膳食补充剂添加到实验室动物的饲料混合物中。研究了膳食补充剂在体内的潜在毒理学作用和降胆固醇、保肝活性。在观察期（6 周）结束时，实验室动物的器官质量和血清均未发生显著变化（>0.05）。然而，高胆固醇指标有所下降。实验室动物定期食用沙棘和玫瑰果油，外加黑加仑提取物（膳食补充剂“ESB-1”），可抑制肝脏酶的活性，提高血清的抗氧化活性（皮下注射葵花籽油/四氯化碳油溶液后），但仍不足以使其达到生理标准。我们膳食补充剂的降胆固醇和抗氧化特性已经使我们能够将其视为功能性食品产品或膳食补充剂的组成部分。然而，其所有生物活性特性（包括保肝功能和代谢紊乱的调节）尚未得到充分研究，这为进一步的体内模型和临床实践研究确定其在人类中的有效性指明了方向。
