National Key Laboratory of Green Pesticide, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for R&D of Fine Chemicals of Guizhou University, Guiyang 550025, China.
School of Chemistry and Chemical Engineering, Qiannan Normal University for Nationalities, Duyun 558000, China.
Molecules. 2023 Jan 15;28(2):876. doi: 10.3390/molecules28020876.
spp. are important plant pathogens that seriously endanger crop yields and food security. RpfF is a key enzyme that is involved in the synthesis of diffusible signal factor (DSF) signals and predominates in the signaling pathway regulating quorum sensing (QS) in . Currently, novel RpfF enzyme-based quorum sensing agents have been proposed as a promising strategy for the development of new pesticides. However, few reports are available that comprehensively summarize the progress in this field. Therefore, we provide a comprehensive review of the recent advances in DSF-mediated QS and recently reported inhibitors that are proposed as bactericide candidates to target the RpfF enzyme and control plant bacterial diseases.
spp. 是重要的植物病原菌,严重威胁作物产量和粮食安全。RpfF 是一种关键酶,参与扩散信号因子 (DSF) 信号的合成,并在调节群体感应 (QS) 的信号通路中占主导地位。目前,新型基于 RpfF 酶的群体感应剂已被提议作为开发新农药的有前途的策略。然而,目前很少有报道全面总结该领域的进展。因此,我们全面回顾了 DSF 介导的 QS 的最新进展以及最近报道的抑制剂,这些抑制剂被提议作为杀菌剂候选物,以针对 RpfF 酶并控制植物细菌性疾病。