Zgoura Panagiota, Seibert Felix S, Waldecker Christoph, Doevelaar Adrian, Bauer Frederic, Rohn Benjamin, Schenker Peter, Wunsch Andreas, Viebahn Richard, Babel Nina, Westhoff Timm H
Medical Department I, Universitätsklinikum Marien Hospital Herne, Ruhr-University Bochum, Bochum, Germany.
Medical Department I, Universitätsklinikum Marien Hospital Herne, Ruhr-University Bochum, Bochum, Germany.
Transplant Proc. 2020 Nov;52(9):2671-2675. doi: 10.1016/j.transproceed.2020.08.043. Epub 2020 Sep 3.
Renal transplant recipients are at increased risk for an adverse course of coronavirus disease 2019 (COVID-19), most likely due to immunosuppression and the high level of cardiovascular comorbidity. Many transplant recipients are aware of these facts. The psychological effects of this knowledge, however, remain elusive.
Cross-sectional study on 62 renal transplant recipients. Fifty cardiovascular outpatients without immunosuppression and 55 healthy subjects served as control. We performed a focused psychological assessment during the pandemic (April 2020) and compared the data with a time 6 months before. Additionally, an intergroup analysis was performed for the data during the pandemic. The analysis was performed by means of a questionnaire derived from KPD-38. We extracted 5 questions focusing on the parameters "life satisfaction" and perceived "action competence." Life satisfaction score ranged from 2 to 8, and the score for action competence from 5 to 20.
Both life satisfaction and perceived action competence were significantly lower during the pandemic than 6 months before in all the 3 groups (P < .005 each). During the pandemic median levels of life satisfaction did not significantly differ between the 3 groups (transplant recipients 6, interquartile range [IQR] 4-7; cardiovascular patients 5, IQR: 4-6; healthy controls 6, IQR 5-7; Kruskal-Wallis P > .05). In contrast, the perceived action competence was higher in healthy subjects (15, IQR 12-17) than in both renal transplant recipients (13, IQR 10-15) and cardiovascular patients (13, IQR 8-14, Kruskal-Wallis P = .0003).
The COVID-19 pandemic has negative effects on life satisfaction and perceived action competence in renal transplant recipients, cardiovascular patients without immunosuppression, and healthy subjects. The effects on life satisfaction in transplant recipients did not differ from nonimmunocompromised patients or healthy controls. In contrast, the feeling of reduced action competence exceeded healthy controls, most likely due to a subjective need for stricter social distancing to avoid infection.
肾移植受者患2019冠状病毒病（COVID - 19）出现不良病程的风险增加，很可能是由于免疫抑制和心血管合并症的高发率。许多移植受者知晓这些情况。然而，这种认知的心理影响仍不明确。
对62名肾移植受者进行横断面研究。50名无免疫抑制的心血管门诊患者和55名健康受试者作为对照。在疫情期间（2020年4月）进行了针对性的心理评估，并将数据与6个月前进行比较。此外，对疫情期间的数据进行了组间分析。分析通过源自KPD - 38的问卷进行。我们提取了5个关注“生活满意度”和感知“行动能力”参数的问题。生活满意度得分范围为2至8分，行动能力得分范围为5至20分。
在所有3组中，疫情期间的生活满意度和感知行动能力均显著低于6个月前（每组P <.005）。疫情期间，3组的生活满意度中位数水平无显著差异（移植受者6分，四分位间距[IQR] 4 - 7；心血管患者5分，IQR：4 - 6；健康对照6分，IQR 5 - 7；Kruskal - Wallis检验P >.05）。相比之下，健康受试者的感知行动能力（15分，IQR 12 - 17）高于肾移植受者（13分，IQR 10 - 15）和心血管患者（13分，IQR 8 - 14，Kruskal - Wallis检验P =.0003）。
COVID - 19疫情对肾移植受者、无免疫抑制的心血管患者和健康受试者的生活满意度和感知行动能力有负面影响。对移植受者生活满意度的影响与非免疫功能低下患者或健康对照无差异。相比之下，行动能力下降的感觉超过了健康对照，很可能是由于为避免感染而主观上需要更严格的社交距离。
