Department of Clinical Nutrition, Suzhou Ninth People's Hospital, Suzhou, 215200, Jiangsu Province, China.
Clinical Medical College, Yangzhou University, Yangzhou, 225009, Jiangsu Province, China.
Biol Trace Elem Res. 2021 Aug;199(8):2837-2843. doi: 10.1007/s12011-020-02413-3. Epub 2020 Oct 2.
The presence of autoimmune thyroid condition could lead to thyroid dysfunction in adults. In addition, thyroid antibody positivity has been suggested to be associated with hyperuricemia, diabetes and obesity in individuals with thyroid autoimmune diseases. Currently, there are limited studies that assessed the relationship of thyroid antibody with the components of metabolic syndrome in adults, especially from iodine-sufficient regions. Therefore, the aim of this study was to determine the prevalence of components of metabolic syndrome in Chinese adults with autoimmune thyroid condition. Medical records of adult inpatients in the Suzhou Ninth People's Hospital, Suzhou, Jiangsu, China, from January 2016 to September 2019 were reviewed and included after screening for eligibility. A total of 1105 participants were included in our final analysis, and of these, 77.5% (n = 856) were females. There was a higher prevalence of thyroid antibodies in females than males (30.6% vs. 23.7%) (p = 0.034). Although there were significant differences in mean TSH, FT3 and FT4 values between participants positive and negative for thyroid antibodies, these values were still within the normal reference range. No differences in the mean BMI, prevalence of diabetes, hyperuricemia, hypertriglyceridemia and hypercholesterolemia between participants positive and negative for thyroid antibodies were reported (p > 0.05). In conclusion, our study reported that participants positive for thyroid antibodies did not appear to be accompanied by abnormal thyroid function, lipid profile, uric acid and glucose concentrations.
自身免疫性甲状腺疾病的存在可能导致成年人甲状腺功能障碍。此外，甲状腺自身抗体阳性已被认为与甲状腺自身免疫疾病患者的高尿酸血症、糖尿病和肥胖有关。目前，评估甲状腺抗体与成年人代谢综合征成分之间关系的研究有限，特别是在碘充足地区。因此，本研究旨在确定中国自身免疫性甲状腺疾病成年患者代谢综合征成分的患病率。对 2016 年 1 月至 2019 年 9 月期间中国江苏苏州第九人民医院住院成年患者的病历进行了回顾性筛选，符合条件的患者纳入本研究。最终纳入 1105 例患者进行分析，其中 77.5%（n=856）为女性。女性甲状腺抗体阳性的比例高于男性（30.6%比 23.7%）（p=0.034）。尽管甲状腺抗体阳性和阴性患者的 TSH、FT3 和 FT4 值的均值存在显著差异，但这些值仍在正常参考范围内。甲状腺抗体阳性和阴性患者的 BMI 均值、糖尿病、高尿酸血症、高甘油三酯血症和高胆固醇血症的患病率无差异（p>0.05）。综上所述，本研究表明，甲状腺抗体阳性的患者似乎没有出现甲状腺功能、血脂谱、尿酸和血糖浓度的异常。
