Francis I. Proctor Foundation.
Department of Ophthalmology, University of California, San Francisco, San Francisco, California, USA.
Curr Opin Ophthalmol. 2020 Nov;31(6):503-507. doi: 10.1097/ICU.0000000000000706.
To revisit ocular rosacea as an underappreciated condition which can cause permanent blindness if inadequately treated, and to review data supporting improved diagnostic and treatment strategies.
Ocular rosacea has an underrecognized prevalence in children and individuals with darker skin tone. Rosacea has several associations with other significant systemic diseases. Variations in local and systemic microbiome, including demodex infestation, may play a role in pathogenesis, severity, and in explaining the different phenotypes of rosacea. The National Rosacea Society Expert Committee established an updated classification system of rosacea in 2017. New treatment algorithms based on these clinical subtypes are suggested.
With continued advancements in the understanding of the epidemiology and pathogenesis of rosacea, randomized controlled trials specific for ocular rosacea remain lacking. There is overall consensus that rosacea and ocular rosacea require chronic maintenance treatment strategies involving combination topical and systemic therapies.
重新审视眼型酒渣鼻,如果治疗不充分,可能导致永久性失明,这是一种被低估的疾病,同时回顾支持改进诊断和治疗策略的数据。
眼型酒渣鼻在儿童和肤色较深的人群中患病率较低,易被忽视。酒渣鼻与其他一些严重的系统性疾病有多种关联。局部和全身微生物组的变化,包括蠕形螨感染,可能在发病机制、严重程度中发挥作用,并解释酒渣鼻的不同表型。2017 年,国家酒渣鼻研究学会专家委员会建立了一个更新的酒渣鼻分类系统。根据这些临床亚型提出了新的治疗方案。
随着对酒渣鼻的流行病学和发病机制的认识不断深入,针对眼型酒渣鼻的随机对照试验仍然缺乏。总的来说,人们普遍认为酒渣鼻和眼型酒渣鼻需要慢性维持治疗策略,包括联合局部和全身治疗。