Department of Maxillofacial Surgery and Diagnostic Sciences, Division of Oral Pathology, College of Dentistry, Jazan University, Jazan, Saudi Arabia.
Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London, UK.
Clin Oral Investig. 2020 Nov;24(11):3833-3841. doi: 10.1007/s00784-020-03608-7. Epub 2020 Oct 3.
The aim of the present study was to systematically review the role of circulating miRNAs as potential prognostic biomarkers in head and neck cancer patients.
PubMed, EMBASE, Scopus, Web of Science, and gray literature from January 1990 up to and including September 2019 were searched. The study selection was performed by two independent reviewers according to eligibility criteria.
A total of 13 studies that met the eligibility criteria were included. Significant number of studies were executed majorly in China and predominant number of them were case-control in nature. A total of 22 different miRNAs were found to be concomitant with very poor prognosis in cancers of the head and neck region. Of these, eighteen miRNAs (miR-375, miR-1234, miR-103, miR-638, miR-200b-3p, miR-191-5p, miR-24-3p, miR-572, miR-483-5p, miR-20a, miR-22, miR-29a, miR-29b, mir-let-7c, miR-17, miR-374b-5p, miR-425-5p, and miR-196a) were upregulated and four miRNAs (miR-9, miR-29c, miR-223, and miR-187∗) were downregulated. The hazard ratio (HR) ranged from twofold to fivefold.
Based on the results, circulating miRNA may assist in the prediction of prognosis of head and neck cancer. Further multi-center randomized controlled clinical trials with large sample size are required to validate the results of the present review.
Decoding the circulating miRNA profile could aid in accurate prognostication of head and neck cancer.
本研究旨在系统地综述循环 miRNA 作为头颈部癌症患者潜在预后生物标志物的作用。
检索了 1990 年 1 月至 2019 年 9 月期间的 PubMed、EMBASE、Scopus、Web of Science 和灰色文献。根据纳入标准，由两名独立评审员进行研究选择。
共有 13 项符合纳入标准的研究被纳入。大量研究主要在中国进行，其中多数为病例对照研究。共有 22 种不同的 miRNA 被发现与头颈部癌症的预后非常差相关。其中，18 种 miRNA（miR-375、miR-1234、miR-103、miR-638、miR-200b-3p、miR-191-5p、miR-24-3p、miR-572、miR-483-5p、miR-20a、miR-22、miR-29a、miR-29b、mir-let-7c、miR-17、miR-374b-5p、miR-425-5p 和 miR-196a）上调，4 种 miRNA（miR-9、miR-29c、miR-223 和 miR-187∗）下调。风险比（HR）范围从两倍到五倍。
基于这些结果，循环 miRNA 可能有助于预测头颈部癌症的预后。需要进一步开展多中心、随机对照临床试验，以验证本综述的结果。
解析循环 miRNA 谱可能有助于对头颈部癌症进行准确的预后预测。
