State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, China; Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing 100029, China; Key Laboratory of Biomedical Materials of Natural Macromolecules, Ministry of Education Beijing, Beijing University of Chemical Technology, 100029, China.
State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, China.
Adv Colloid Interface Sci. 2020 Nov;285:102280. doi: 10.1016/j.cis.2020.102280. Epub 2020 Sep 28.
Hydrogels have emerged as promising antimicrobial materials due to their unique three-dimensional structure, which provides sufficient capacity to accommodate various materials, including small molecules, polymers and particles. Coating substrates with antibacterial hydrogel layers has been recognized as an effective strategy to combat bacterial colonization. To prevent possible delamination of hydrogel coatings from substrates, it is crucial to attach hydrogel layers via stronger links, such as covalent bonds. To date, various surface chemical strategies have been developed to introduce hydrogel coatings on different substrates. In this review, we first give a brief introduction of the major strategies for designing antibacterial coatings. Then, we summarize the chemical methods used to fix the antibacterial hydrogel layer on the substrate, which include surface-initiated graft crosslinking polymerization, anchoring the hydrogel layer on the surface during crosslinking, and chemical crosslinking of layer-by-layer coating. The reaction mechanisms of each method and matched pretreatment strategies are systemically documented with the aim of introducing available protocols to researchers in related fields for designing hydrogel-coated antibacterial surfaces.
水凝胶因其独特的三维结构而成为有前途的抗菌材料，这种结构为容纳各种材料提供了充足的空间，包括小分子、聚合物和颗粒。在基底上涂覆抗菌水凝胶层已被认为是对抗细菌定植的有效策略。为了防止水凝胶涂层可能从基底上分层，通过更强的键，如共价键，将水凝胶层附着在基底上是至关重要的。迄今为止，已经开发了各种表面化学策略来在不同的基底上引入水凝胶涂层。在这篇综述中，我们首先简要介绍了设计抗菌涂层的主要策略。然后，我们总结了将抗菌水凝胶层固定在基底上的化学方法，包括表面引发接枝交联聚合、在交联过程中将水凝胶层锚定在表面上，以及层层涂层的化学交联。系统地记录了每种方法的反应机制和匹配的预处理策略，目的是为相关领域的研究人员介绍可用的方案，以设计水凝胶涂覆的抗菌表面。
