State Key Laboratory of Respiratory Disease, National Clinical Research Centre for Respiratory Disease, Guangzhou Institute of Respiratory Health, Department of Respiratory and Critical Care Medicine, First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Thorac Cancer. 2019 May;10(5):1272-1275. doi: 10.1111/1759-7714.13048. Epub 2019 Mar 30.
An extracranial abscopal effect induced by brain radiotherapy is particularly unusual because of the brain's distinctive immune microenvironment. We report a case of an extracranial abscopal effect in a 71-year-old male patient with lung adenocarcinoma treated with atezolizumab and later combined with brain radiation for brain metastasis. The subsequent abscopal effect first manifested as pseudoprogression of the primary lesion in the lung before remission was confirmed. This case suggests that immunotherapy increases the chance of an abscopal effect occurring after radiation therapy for brain metastases in patients with primary tumors with low immunogenicity.
脑放疗引起的颅外远隔效应特别罕见，因为大脑具有独特的免疫微环境。我们报告了一例肺腺癌患者的颅外远隔效应病例，该患者接受 atezolizumab 治疗，随后联合脑部放疗治疗脑转移。随后的远隔效应首先表现为肺部原发病灶的假性进展，然后才确认缓解。该病例提示，对于原发肿瘤免疫原性低的脑转移患者，免疫治疗增加了放疗后发生远隔效应的机会。
