Ashique Sumel, Sandhu Navjot Kaur, Haque Sk Niyamul, Koley Kartick
Department of Pharmaceutics, ISF College of Pharmacy, Moga, Punjab, 142001, India.
Department of Quality Assurance and Pharmaceutical Analysis, ISF College of Pharmacy, Moga, Punjab, 142001, India.
Nat Prod Bioprospect. 2020 Dec;10(6):345-365. doi: 10.1007/s13659-020-00267-9. Epub 2020 Oct 4.
Androgens have an intense consequence on the human scalp and body hair. Scalp hair sprouts fundamentally in awol of androgens whereas the body hair hike is vulnerable to the activity of androgens. Androgenetic alopecia (AGA) invoked as males emulate Alopecia due to the cause of the dynamic reduction of scalp hair. Androgens are medium of terminus growth of hair although the body. Local and system androgens convert the extensive terminal follicles into lesser vellus like structure. The out start of this type of alopecia is intensely irregular and the reason behind this existence of enough circulating steroidal hormones androgens and due to genetic predisposition. Effective treatments are available in the market as well as under clinical and preclinical testing. Many herbal formulations are also available but not FDA approved. Different conventional and NDDS formulations are already available in the market. To avoid various systemic side effects of both Finasteride and Minoxidil, topical formulations and natural products (nutrients, minerals, vitamins) now a days are being widely used to treat Androgenic alopecia. CAM (complementary and alternative medicine) provides the option to elect favorable, low-risk, adjuvant and alternative therapies. Herein, we offer a widespread review of topical marketed formulations, natural products, and CAM treatment options for AGA.
雄激素对人类头皮和身体毛发有显著影响。头皮毛发的生长基本上处于雄激素缺乏的状态,而身体毛发的增加则易受雄激素活性的影响。男性型雄激素性脱发(AGA)是由于头皮毛发动态减少而引发的脱发。雄激素是身体毛发终末生长的介质。局部和全身的雄激素会将广泛的终末毛囊转化为较小的毳毛样结构。这种脱发的起始非常不规则,其存在的原因是有足够的循环甾体激素雄激素以及遗传易感性。市场上有有效的治疗方法,同时也在进行临床和临床前测试。也有许多草药配方,但未获美国食品药品监督管理局(FDA)批准。市场上已经有不同的传统制剂和新型药物递送系统(NDDS)制剂。为了避免非那雄胺和米诺地尔的各种全身副作用,如今局部制剂和天然产品(营养素、矿物质、维生素)被广泛用于治疗雄激素性脱发。补充和替代医学(CAM)提供了选择有利、低风险、辅助和替代疗法的选项。在此,我们对AGA的局部上市制剂、天然产品和CAM治疗选择进行广泛综述。