Lin Yali, Shao Ruomei, Xiao Tong, Sun Shuqing
Institute of Biopharmaceutical and Health Engineering, Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China.
Department of Biomedical Engineering, Tsinghua University, Beijing 100084, China.
Pharmaceutics. 2022 Jul 4;14(7):1404. doi: 10.3390/pharmaceutics14071404.
Interest in transdermal delivery methods for stimulating hair regrowth has been increasing recently. The microneedle approach can break the barrier of the stratum corneum through puncture ability and improve drug delivery efficiency. Herein, we report a dissolvable microneedle device for the co-delivery of rapamycin and epigallocatechin gallate nanoparticles that can significantly promote hair regeneration. Compared with the mice without any treatment, our strategy can facilitate hair growth within 7 days. Higher hair shaft growth rate and hair follicle density with inconspicuous inflammation were exhibited in C57BL/6 mice, elucidating its potential for clinical application.
最近，人们对用于刺激头发生长的透皮给药方法的兴趣日益增加。微针方法可以通过穿刺能力打破角质层屏障，提高药物递送效率。在此，我们报告一种可溶解的微针装置，用于共同递送雷帕霉素和表没食子儿茶素没食子酸酯纳米颗粒，该装置可显著促进毛发再生。与未接受任何治疗的小鼠相比，我们的策略可在7天内促进头发生长。C57BL/6小鼠表现出更高的毛干生长速率和毛囊密度，且炎症不明显，这阐明了其临床应用潜力。
