Clinic of Internal Diseases, Family Medicine and Oncology, Vilnius University Faculty of Medicine, Vilnius, Lithuania.
Int J Clin Pract. 2021 Mar;75(3):e13748. doi: 10.1111/ijcp.13748. Epub 2020 Oct 27.
Vitamin D (VitD) deficiency is considered a global problem and might be associated with increased susceptibility to COVID-19 illness. In the light of COVID-19 pandemic, VitD might be a promising agent for fighting the SARS-CoV-2, since VitD is involved in various pathophysiological mechanisms that occur during COVID-19 infection. High-dose VitD supplementation, particularly for risk groups, could be recommended to achieve and maintain optimal (range 40-60 ng/mL) serum 25-hydroxy vitamin D levels (marker of VitD status) both for COVID-19 prevention and treatment.
维生素 D（VitD）缺乏被认为是一个全球性问题，可能与 COVID-19 疾病的易感性增加有关。鉴于 COVID-19 大流行，VitD 可能是对抗 SARS-CoV-2 的有前途的药物，因为 VitD 参与了 COVID-19 感染期间发生的各种病理生理机制。建议高危人群进行高剂量 VitD 补充，以达到并维持最佳（40-60ng/ml 范围）血清 25-羟维生素 D 水平（VitD 状态标志物），以预防和治疗 COVID-19。
