用于评估角膜内伤口愈合情况的纳米敏感光学相干断层扫描技术。
Nanosensitive optical coherence tomography to assess wound healing within the cornea.
作者信息
Lal Cerine, Alexandrov Sergey, Rani Sweta, Zhou Yi, Ritter Thomas, Leahy Martin
机构信息
Tissue Optics and Microcirculation Imaging Facility, National Biophotonics and Imaging Platform, School of Physics, National University of Ireland, Galway, Ireland.
Regenerative Medicine Institute, National University of Ireland, Galway, Ireland.
出版信息
Biomed Opt Express. 2020 Jun 2;11(7):3407-3422. doi: 10.1364/BOE.389342. eCollection 2020 Jul 1.
Abstract
Optical coherence tomography (OCT) is a non-invasive depth resolved optical imaging modality, that enables high resolution, cross-sectional imaging in biological tissues and materials at clinically relevant depths. Though OCT offers high resolution imaging, the best ultra-high-resolution OCT systems are limited to imaging structural changes with a resolution of one micron within very limited depth. Nanosensitive OCT (nsOCT) is a recently developed technique that is capable of providing enhanced sensitivity of OCT to structural changes. Improving the sensitivity of OCT to detect structural changes at the nanoscale level, to a depth typical for conventional OCT, could potentially improve the diagnostic capability of OCT in medical applications. In this paper, we demonstrate the capability of nsOCT to detect structural changes deep in the rat cornea following superficial corneal injury.
摘要
光学相干断层扫描（OCT）是一种非侵入性的深度分辨光学成像方式，能够在临床相关深度对生物组织和材料进行高分辨率的横截面成像。尽管OCT提供高分辨率成像，但最佳的超高分辨率OCT系统仅限于在非常有限的深度内以一微米的分辨率对结构变化进行成像。纳米敏感OCT（nsOCT）是一种最近开发的技术，能够增强OCT对结构变化的敏感性。提高OCT在纳米尺度水平上检测结构变化的敏感性，达到传统OCT的典型深度，可能会提高OCT在医学应用中的诊断能力。在本文中，我们展示了nsOCT检测大鼠角膜浅表损伤后深层结构变化的能力。
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