Durack Juliana, Christophersen Claus T
Symbiome Inc., San Francisco, CA, United States.
Division of Gastroenterology, Department of Medicine, University of California, San Francisco, San Francisco, CA, United States.
Front Pediatr. 2020 Sep 3;8:528. doi: 10.3389/fped.2020.00528. eCollection 2020.
Human gastrointestinal and respiratory tracts are colonized by diverse polymicrobial communities shortly after birth, which are continuously molded by environmental exposure. The development of the resident microbiota in early life is a critical factor in the maturation of a healthy immune system. Disturbances to the intricate relationship between environmental exposure and maturation of the infant microbiome have been increasingly identified as a potential contributor to a range of childhood diseases. This review details recent evidence that implicates the contribution of gut and airway microbiome to pediatric respiratory health.
人类胃肠道和呼吸道在出生后不久就被多种微生物群落定植，这些群落会随着环境暴露而不断塑造。生命早期常驻微生物群的发育是健康免疫系统成熟的关键因素。环境暴露与婴儿微生物组成熟之间复杂关系的紊乱越来越被认为是一系列儿童疾病的潜在促成因素。这篇综述详细介绍了近期表明肠道和气道微生物组对儿童呼吸道健康有影响的证据。
