School of Environment and Science, Griffith University , Gold Coast, Australia.
Therapeutics Research Centre, The University of Queensland Diamantina Institute, Translational Research Institute , Brisbane, Australia.
Expert Opin Drug Metab Toxicol. 2021 Jan;17(1):105-119. doi: 10.1080/17425255.2020.1832081. Epub 2020 Dec 3.
In the past, mathematical modeling of the transport of transdermal drugs has been primarily focused on the stratum corneum. However, the development of pharmaceutical technologies, such as chemical enhancers, iontophoresis, and microneedles, has led to two outcomes; an increase in permeability in the stratum corneum or the ability to negate the layer entirely. As a result, these outcomes have made the transport of a solute in the viable skin far more critical when studying transdermal drug delivery.
The review will explicitly show the various attempts to model drug transport within the viable skin. Furthermore, a brief review will be conducted on the different models that explain stratum corneum transport, microneedle dynamics and estimation of the diffusion coefficient.
Future development of mathematical models requires the focus to be changed from traditional diffusion-based tissue models to more sophisticated three-dimensional models that incorporate the physiology of the skin.
过去，经皮药物传输的数学建模主要集中在角质层上。然而，药物技术的发展，如化学增强剂、离子电渗和微针，导致了两种结果；角质层的通透性增加，或者完全去除角质层的能力。因此，在研究经皮药物传递时，这些结果使得研究溶质在可穿透皮肤中的传输变得更加重要。
本综述将明确展示各种尝试在可穿透皮肤中对药物传输进行建模的方法。此外，还将简要回顾解释角质层传输、微针动力学和扩散系数估计的不同模型。
数学模型的未来发展需要将重点从传统的基于扩散的组织模型转移到更复杂的三维模型，这些模型将纳入皮肤的生理学。
