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以过敏性紫癜为表现的肺结核:病例报告及文献复习

Pulmonary tuberculosis presenting as henoch-schönlein purpura: Case report and literature review.

作者信息

Li Jie, Wang Xiao-Zi, Wang Rui-Cang, Yang Jie, Hao Hong-Ling, Xue Li-Ying

机构信息

Department of Hematology, Hebei General Hospital.

Department of Pathology, Hebei Medical University, Shijiazhuang, China.

出版信息

Medicine (Baltimore). 2020 Oct 2;99(40):e22583. doi: 10.1097/MD.0000000000022583.

Abstract

INTRODUCTION

Henoch-Schönlein purpura (HSP) is an extremely rare condition in patients with pulmonary tuberculosis, with only a few reported cases. Compared to patients with typical clinical symptoms, it is difficult to make a definitive diagnosis when HSP presents as an initial manifestation in pulmonary tuberculosis patients. Herein, a case of pulmonary tuberculosis that showed HSP at first was reported, and the related literatures were reviewed.

PATIENT CONCERNS

A 24-year-old man presented with palpable purpura on the extremities, accompanied by abdominal pain, bloody stools, and knee pain.

DIAGNOSES

The patient was diagnosed with pulmonary tuberculosis based on the results of interferon gamma release assays, purified protein derivative test, and computed tomography.

INTERVENTIONS

The patient was treated with vitamin C and chlorpheniramine for 2 weeks, and the above-mentioned symptoms were relieved. However, 3 weeks later, the purpura recurred with high-grade fever and chest pain during the inspiratory phase. The patient was then treated with anti-tuberculosis drugs, and the purpura as well as the high fever disappeared.

OUTCOMES

The patient recovered well and remained free of symptoms during the follow-up examination.

CONCLUSION

Pulmonary tuberculosis presenting with HSP as an initial manifestation is not common. Therefore, it is difficult to clinically diagnose and treat this disease. When an adult patient shows HSP, it is important to consider the possibility of tuberculosis to avoid misdiagnosis and delayed treatment.

摘要

引言

过敏性紫癜(HSP)在肺结核患者中极为罕见,仅有少数病例报道。与具有典型临床症状的患者相比,当HSP作为肺结核患者的初始表现时,很难做出明确诊断。本文报道了一例最初表现为HSP的肺结核病例,并对相关文献进行了复习。

患者情况

一名24岁男性,四肢出现可触及的紫癜,伴有腹痛、便血和膝关节疼痛。

诊断

根据干扰素γ释放试验、结核菌素试验和计算机断层扫描结果,该患者被诊断为肺结核。

干预措施

患者接受维生素C和氯苯那敏治疗2周,上述症状缓解。然而,3周后,紫癜复发,伴有高热和吸气期胸痛。随后患者接受抗结核药物治疗,紫癜和高热消失。

结果

患者恢复良好,随访检查期间无症状。

结论

以HSP为初始表现的肺结核并不常见。因此,该病在临床诊断和治疗上存在困难。当成年患者出现HSP时,考虑结核病的可能性很重要,以避免误诊和延误治疗。

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