Huang Chuanlin, Zhou Wenjuan, Wu Riliga, Guan Weijiang, Ye Nengsheng
Department of Chemistry, Capital Normal University, Beijing 100048, China.
State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, China.
Nanomaterials (Basel). 2023 May 25;13(11):1726. doi: 10.3390/nano13111726.
Reactive oxygen species (ROS) play important roles in organisms and are closely related to various physiological and pathological processes. Due to the short lifetime and easy transformation of ROS, the determination of ROS content in biosystem has always been a challenging task. Chemiluminescence (CL) analysis has been widely used in the detection of ROS due to its advantages of high sensitivity, good selectivity and no background signal, among which nanomaterial-related CL probes are rapidly developing. In this review, the roles of nanomaterials in CL systems are summarized, mainly including their roles as catalysts, emitters, and carriers. The nanomaterial-based CL probes for biosensing and bioimaging of ROS developed in the past five years are reviewed. We expect that this review will provide guidance for the design and development of nanomaterial-based CL probes and facilitate the wider application of CL analysis in ROS sensing and imaging in biological systems.
活性氧（ROS）在生物体中发挥着重要作用，并且与各种生理和病理过程密切相关。由于ROS的寿命短且易于转化，生物系统中ROS含量的测定一直是一项具有挑战性的任务。化学发光（CL）分析因其具有高灵敏度、良好的选择性和无背景信号等优点，已被广泛应用于ROS的检测，其中与纳米材料相关的CL探针发展迅速。在这篇综述中，总结了纳米材料在CL体系中的作用，主要包括它们作为催化剂、发光体和载体的作用。综述了过去五年中开发的用于ROS生物传感和生物成像的基于纳米材料的CL探针。我们期望这篇综述将为基于纳米材料的CL探针的设计和开发提供指导，并促进CL分析在生物系统中ROS传感和成像中的更广泛应用。
