溶组织内阿米巴的阶段转换：进展与新见解。
Entamoeba stage conversion: progress and new insights.
作者信息
Manna Dipak, Ehrenkaufer Gretchen M, Lozano-Amado Daniela, Singh Upinder
机构信息
Division of Infectious Diseases, Stanford University School of Medicine, United States.
Division of Infectious Diseases, Stanford University School of Medicine, United States; Department of Microbiology and Immunology, Stanford University School of Medicine, United States.
出版信息
Curr Opin Microbiol. 2020 Dec;58:62-68. doi: 10.1016/j.mib.2020.09.005. Epub 2020 Oct 6.
Abstract
Entamoeba histolytica, an anaerobic protozoan, is an important global health problem. This parasite has a biphasic life cycle consisting of a dormant cyst stage which is environmentally resistant and transmits the infection, and the proliferative trophozoite stage which is motile and causes invasive disease. The stage conversion process remains poorly understood despite being central to amoebic biology. In this review, we will highlight recent progress in our understanding of Entamoeba stage conversion including dissecting transcriptome analysis in development, characterization of transcriptional networks, demonstration of epigenetic regulation, and role of small molecules that regulate Entamoeba development.
摘要
溶组织内阿米巴是一种厌氧原生动物，是一个重要的全球健康问题。这种寄生虫具有双相生命周期，包括在环境中具有抵抗力并传播感染的休眠包囊阶段，以及具有运动性并导致侵袭性疾病的增殖滋养体阶段。尽管阶段转换过程是阿米巴生物学的核心，但对其仍知之甚少。在这篇综述中，我们将重点介绍我们在理解溶组织内阿米巴阶段转换方面的最新进展，包括剖析发育过程中的转录组分析、转录网络的特征、表观遗传调控的证明以及调节溶组织内阿米巴发育的小分子的作用。
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