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大鼠肺中降钙素基因相关肽免疫反应性：光镜和电镜研究

Calcitonin gene related peptide immunoreactivity in rat lung: light and electron microscopic study.

作者信息

Lauweryns J M, van Ranst L

出版信息

Thorax. 1987 Mar;42(3):183-9. doi: 10.1136/thx.42.3.183.

DOI:10.1136/thx.42.3.183
PMID:3303426
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC460686/
Abstract

Calcitonin gene related peptide immunoreactivity was investigated in the rat lung. Immunoreactive material was observed in nerve fibres surrounding bronchi, bronchioli, and blood vessels, and also in neuroendocrine cells and neuroepithelial bodies. In addition, the peptide was identified by immunoelectron microscopy in dense cored vesicles of granulated cells of the neuroepithelial bodies. These observations suggest that calcitonin gene related peptide plays a part in the regulatory function of the rat respiratory tract, exerting its influence by endocrine, paracrine, neurosecretory pathways, or a combination of these.

摘要

在大鼠肺中研究了降钙素基因相关肽免疫反应性。在支气管、细支气管和血管周围的神经纤维中以及神经内分泌细胞和神经上皮小体中观察到免疫反应物质。此外，通过免疫电子显微镜在神经上皮小体颗粒细胞的致密核心囊泡中鉴定出该肽。这些观察结果表明，降钙素基因相关肽在大鼠呼吸道的调节功能中起作用，通过内分泌、旁分泌、神经分泌途径或这些途径的组合发挥其影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a00/460686/820c4e2a238b/thorax00255-0027-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a00/460686/9d1b3a8e9161/thorax00255-0025-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a00/460686/ef1b40e1cf12/thorax00255-0025-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a00/460686/3b852d0e996f/thorax00255-0025-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a00/460686/ee60b1f69b7e/thorax00255-0025-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a00/460686/4a9980c58cfc/thorax00255-0026-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a00/460686/f4cd99765801/thorax00255-0026-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a00/460686/83267772c8c5/thorax00255-0027-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a00/460686/820c4e2a238b/thorax00255-0027-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a00/460686/9d1b3a8e9161/thorax00255-0025-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a00/460686/ef1b40e1cf12/thorax00255-0025-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a00/460686/3b852d0e996f/thorax00255-0025-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a00/460686/ee60b1f69b7e/thorax00255-0025-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a00/460686/4a9980c58cfc/thorax00255-0026-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a00/460686/f4cd99765801/thorax00255-0026-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a00/460686/83267772c8c5/thorax00255-0027-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a00/460686/820c4e2a238b/thorax00255-0027-b.jpg

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